Literature DB >> 4973231

Properties of thiol-subtilisin. The consequences of converting the active serine residue to cysteine in a serine protease.

K E Neet, A Nanci, D E Koshland.   

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Year:  1968        PMID： 4973231

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


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  13 in total

1.  Inactivation of the thiol RTEM-1 beta-lactamase by 6-beta-bromopenicillanic acid. Identity of the primary active-site nucleophile.

Authors:  A K Knap; R F Pratt
Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857

2.  A source for the special catalytic power of enzymes: orbital steering.

Authors:  D R Storm; D E Koshland
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

3.  Active-site serine mutants of the Streptomyces albus G beta-lactamase.

Authors:  F Jacob; B Joris; J M Frère
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

4.  Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole.

Authors:  Paul A Sigala; Daniel A Kraut; Jose M M Caaveiro; Brandon Pybus; Eliza A Ruben; Dagmar Ringe; Gregory A Petsko; Daniel Herschlag
Journal:  J Am Chem Soc       Date:  2008-09-23       Impact factor: 15.419

5.  Mushroom tyrosinase oxidizes tyrosine-rich sequences to allow selective protein functionalization.

Authors:  Marcus J C Long; Lizbeth Hedstrom
Journal:  Chembiochem       Date:  2012-07-17       Impact factor: 3.164

6.  Theoretical aspects of orbital steering.

Authors:  A Dafforn; D E Koshland
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

7.  The nature of general base-general acid catalysis in serine proteases.

Authors:  L Polgár; M L Bender
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205

8.  Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides.

Authors:  Yoshio Takeuchi; Tomoya Fujiwara; Yoshihito Shimone; Hideki Miyataka; Toshio Satoh; Kenneth L Kirk; Hitoshi Hori
Journal:  Bioorg Med Chem Lett       Date:  2008-10-05       Impact factor: 2.823

9.  Evidence that the lack of high catalytic activity of thiolsubtilisin towards specific substrates may be due to an inappropriately located proton-distribution system. Demonstration of highly nucleophilic character of the thiol group of thiolsubtilisin in the catalytically relevant ionization state of the active centre by use of a two-protonic-state reactivity probe.

Authors:  K Brocklehurst; J P Malthouse
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857

Review 10.  Kinetics of subtilisin and thiolsubtilisin.

Authors:  M Philipp; M L Bender
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396
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