Literature DB >> 496899

The distribution of glutathione in the rat liver lobule.

M T Smith, N Loveridge, E D Wills, J Chayen.   

Abstract

A quantitative cytochemical method was developed for measuring the GSH (reduced glutathione) content of hepatocytes in different regions of the rat liver lobule. Use of this method enabled us to show that GSH is not evenly distributed within the rat liver lobule. The hepatocytes located within 100 micrometer of the central vein contain much less GSH than do those in other regions of the rat liver lobule. We suggest that this partially explains the peculiar susceptibility of these cells to electrophilic attack by toxic metabolites formed via the microsomal cytochrome P-450 system.

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Year:  1979        PMID： 496899      PMCID： PMC1161238          DOI： 10.1042/bj1820103

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Improved method for the determination of blood glutathione.

Authors:  E BEUTLER; O DURON; B M KELLY
Journal:  J Lab Clin Med       Date:  1963-05

2.  Tissue sulfhydryl groups.

Authors:  G L ELLMAN
Journal:  Arch Biochem Biophys       Date:  1959-05       Impact factor: 4.013

3.  A rapid procedure for the determination of adrenal ascorbic acid. Application of the Sullivan and Clarke method to tissues.

Authors:  R P MAICKEL
Journal:  Anal Biochem       Date:  1960-12-30       Impact factor: 3.365

4.  Cytochrome P-450 distribution in rat liver and the effect of sodium phenobarbitone administration.

Authors:  P E Gooding; J Chayen; B Sawyer; T F Slater
Journal:  Chem Biol Interact       Date:  1978-03       Impact factor: 5.192

Review 5.  The nature and distribution of enzymes catalyzing the conjugation of glutathione with foreign compounds.

Authors:  L F Chasseaud
Journal:  Drug Metab Rev       Date:  1973       Impact factor: 4.518

6.  Histochemical demonstration of enzymes related to NADPH-dependent hydroxylating systems in rat liver after phenobarbital treatment.

Authors:  J Koudstaal; M J Hardonk
Journal:  Histochemie       Date:  1969

7.  A rapid micromethod for the determination of ascorbic acid in plasma and tissues.

Authors:  V Zannoni; M Lynch; S Goldstein; P Sato
Journal:  Biochem Med       Date:  1974-09

Review 8.  The cytochemical approach to hormone assay.

Authors:  J Chayen
Journal:  Int Rev Cytol       Date:  1978

9.  Possible mechanism of liver necrosis caused by aromatic organic compounds.

Authors:  B B Brodie; W D Reid; A K Cho; G Sipes; G Krishna; J R Gillette
Journal:  Proc Natl Acad Sci U S A       Date:  1971-01       Impact factor: 11.205

10.  Histochemical localization of glutathione in tissues.

Authors:  K Asghar; B G Reddy; G Krishna
Journal:  J Histochem Cytochem       Date:  1975-10       Impact factor: 2.479
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  16 in total

1.  Variation of alpha 1-antitrypsin glycoprotein microheterogeneity in hepatic postresuscitation disease.

Authors:  K Heyne; F K Tegtmeyer; S Weidinger
Journal:  Eur J Pediatr       Date:  1990-08       Impact factor: 3.183

2.  The effects of cisplatin on the concentration of protein thiols and glutathione in the rat kidney.

Authors:  P Mistry; Y Merazga; D J Spargo; P A Riley; D C McBrien
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

3.  Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes.

Authors:  Y Kera; K E Penttilä; K O Lindros
Journal:  Biochem J       Date:  1988-09-01       Impact factor: 3.857

4.  Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.

Authors:  O B Usta; W J McCarty; S Bale; M Hegde; R Jindal; A Bhushan; I Golberg; M L Yarmush
Journal:  Technology (Singap World Sci)       Date:  2015-03

5.  The use of an inexpensive, general purpose microcomputer in quantitative cytochemistry.

Authors:  M T Smith; E D Wills; K Drew; C Maxwell; J R Daly; S C Reader; W R Robertson
Journal:  Histochemistry       Date:  1980

Review 6.  Cytochemical detection of cancer: a review.

Authors:  L Bitensky; J Chayen; O A Husain
Journal:  J R Soc Med       Date:  1984-08       Impact factor: 5.344

7.  Inhibition by sporidesmin of hepatocyte bile acid transport.

Authors:  S J Cordiner; T W Jordan
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

8.  Glutathione localization by a novel o-phthalaldehyde histofluorescence method.

Authors:  G I Murray; M D Burke; S W Ewen
Journal:  Histochem J       Date:  1986-08

9.  Periportal- and perivenous-enriched hepatocyte couplets: differences in canalicular activity and in response to oxidative stress.

Authors:  J C Wilton; J K Chipman; C J Lawson; A J Strain; R Coleman
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

10.  Fluorescence-activated sorting of rat hepatocytes based on their mixed function oxidase activities towards diethoxyfluorescein.

Authors:  I N White; M L Green; R F Legg
Journal:  Biochem J       Date:  1987-10-01       Impact factor: 3.857
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