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Literature DB >> 4949483

Effect of endotoxin on pyruvate kinase activity in mouse liver.

Abstract

The pyruvate kinase (PK) activity of mouse liver increases after injection of endotoxin. It decreases in animals given cortisone alone and remains essentially unchanged in those given cortisone and endotoxin at the same time. CCl(4) causes an increase in liver PK activity, but neither it nor endotoxin changes the activity of muscle PK. Addition of octonoate to liver homogenates inhibits the activity of liver PK. These results suggest that the rapid depletion in liver glycogen after administration of endotoxin or CCl(4) may be related to increased PK activity. Induction of tolerance does not prevent the increase in liver PK activity in challenged animals.

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Year: 1971 PMID： 4949483 PMCID： PMC416277 DOI： 10.1128/iai.4.2.138-142.1971

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. INSULIN: INDUCER OF PYRUVATE KINASE.

Authors: G WEBER; N B STAMM; E A FISHER
Journal: Science Date: 1965-07-02 Impact factor: 47.728

2. Leukocyte adenosine triphosphatases and the effect of endotoxin on their activity.

Authors: S R Tenney; G W Rafter
Journal: Arch Biochem Biophys Date: 1968-07 Impact factor: 4.013

3. Inhibition of hepatic enzyme induction as a sensitive assay for endotoxin.

Authors: L J Berry; D S Smythe; L S Colwell
Journal: J Bacteriol Date: 1968-10 Impact factor: 3.490

Review 4. Synchronous behavior pattern of key glycolytic enzymes: glucokinase, phosphofructokinase, and pyruvate kinase.

Authors: G Weber; R L Singhal; N B Stamm; M A Lea; E A Fisher
Journal: Adv Enzyme Regul Date: 1966

5. Feedback inhibition of key glycolytic enzymes in liver: action of free fatty acids.

Authors: G Weber; H J Convery; M A Lea; N B Stamm
Journal: Science Date: 1966-12-09 Impact factor: 47.728

6. Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues.

Authors: T Tanaka; Y Harano; F Sue; H Morimura
Journal: J Biochem Date: 1967-07 Impact factor: 3.387

7. Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.

Authors: J W Shands; V Miller; H Martin; V Senterfitt
Journal: J Bacteriol Date: 1969-05 Impact factor: 3.490

8. Enhancing effect of insulin on endotoxin lethality.

Authors: R E Pieroni; L Levine
Journal: Experientia Date: 1969-05-15

9. Influence of carbon tetrachloride on inducible liver enzymes and response to endotoxin in mice.

Authors: I S Synder; M K Agarwal; L J Berry
Journal: J Bacteriol Date: 1967-12 Impact factor: 3.490

10. Effect of bacterial endotoxin on metabolism. II Protein-carbohydrate balance following cortisone. Inhibition of intestinal absorption and adrenal response to ACTH.

Authors: L J BERRY; D S SMYTHE
Journal: J Exp Med Date: 1959-09-01 Impact factor: 14.307

12 in total

10. Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells.

Authors: E D Ceppi; R G Knowles; K M Carpenter; M A Titheradge
Journal: Biochem J Date: 1992-06-15 Impact factor: 3.857

Effect of endotoxin on pyruvate kinase activity in mouse liver.

1. INSULIN: INDUCER OF PYRUVATE KINASE.

2. Leukocyte adenosine triphosphatases and the effect of endotoxin on their activity.

3. Inhibition of hepatic enzyme induction as a sensitive assay for endotoxin.

Review 4. Synchronous behavior pattern of key glycolytic enzymes: glucokinase, phosphofructokinase, and pyruvate kinase.

5. Feedback inhibition of key glycolytic enzymes in liver: action of free fatty acids.

6. Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues.

7. Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice.

8. Enhancing effect of insulin on endotoxin lethality.

9. Influence of carbon tetrachloride on inducible liver enzymes and response to endotoxin in mice.

10. Effect of bacterial endotoxin on metabolism. II Protein-carbohydrate balance following cortisone. Inhibition of intestinal absorption and adrenal response to ACTH.

1. Roles of interleukin-1 and tumor necrosis factor in lipopolysaccharide-induced hypoglycemia.

2. Carbohydrate metabolism and survival of endotoxin-poisoned mice given tryptophan.

3. Effect of lipopolysaccharide and lipid A on mouse liver pyruvate kinase activity.

4. Fate of 51Cr-labeled lipopolysaccharide in tissue culture cells and livers of normal mice.

5. Effects of endotoxin on gluconeogenesis, glycogen synthesis, and liver glycogen synthase in mice.

6. Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock.

7. Comparative dynamics of salmonella infection after primary and secondary challenge of mice exposed to 10 and 23 C.

8. Enzyme activities of the livers of mice infected with Salmonella typhimurium.

9. Study of inhibition of induction of phosphoenolpyruvate carboxykinase by endotoxin with radial immunodiffusion.

10. Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells.