Literature DB >> 4941982

Uridine diphosphate-4-keto-glucose, an intermediate in the uridine diphosphate-galactose-4-epimerase reaction.

U S Maitra, H Ankel.   

Abstract

When UDP-galactose 4-epimerase (EC 5.1.3.2) from Escherichia coli is incubated with UDP-galactose, then reduced with NaB(3)H(4), label is found in UDP-glucose and UDP-galactose. Enzymatic and chemical degradation demonstrates that the label is bound to carbon 4 of the glycosyl moieties. These results provide direct evidence for the existence of UDP-4-keto-glucose as an enzyme-bound intermediate in the epimerization reaction, and they exclude the formation of a 3-keto intermediate.

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Year:  1971        PMID： 4941982      PMCID： PMC389495          DOI： 10.1073/pnas.68.11.2660

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  THE ENZYMES OF THE GALACTOSE OPERON IN ESCHERICHIA COLI. I. PURIFICATION AND CHARACTERIZATION OF URIDINE DIPHOSPHOGALACTOSE 4-EPIMERASE.

Authors:  D B WILSON; D S HOGNESS
Journal:  J Biol Chem       Date:  1964-08       Impact factor: 5.157

2.  SPECIFIC ACTIVITY DETERMINATION OF RADIOACTIVE FORMIC ACID.

Authors:  O GABRIEL
Journal:  Anal Biochem       Date:  1965-01       Impact factor: 3.365

3.  The enzymic interconversion of uridine diphosphogalactose and uridine diphosphoglucose.

Authors:  E S MAXWELL
Journal:  J Biol Chem       Date:  1957-11       Impact factor: 5.157

4.  Enzymatic formation of uridine diphosphoglucuronic acid.

Authors:  J AXELROD; H M KALCKAR; E S MAXWELL; J L STROMINGER
Journal:  J Biol Chem       Date:  1957-01       Impact factor: 5.157

5.  On the mechanism of the UDP-D-glucose-4'-epimerase. Evidence for a 3-keto-hexose intermediate.

Authors:  L Davis; L Glaser
Journal:  Biochem Biophys Res Commun       Date:  1971-06-18       Impact factor: 3.575

6.  Biosynthesis of uridine diphosphate D-xylose. IV. Mechanism of action of uridine diphosphoglucuronate carboxy-lyase.

Authors:  J S Schutzbach; D S Feingold
Journal:  J Biol Chem       Date:  1970-05-25       Impact factor: 5.157

7.  Biosynthesis of uridine diphosphate D-xylose. II. Uridine diphosphate D-glucuronate carboxy-lyase of Cryptococcus laurentii.

Authors:  H Ankel; D S Feingold
Journal:  Biochemistry       Date:  1966-01       Impact factor: 3.162

8.  Uridine diphosphoglucose 4-epimerase: kinetic isotope effect.

Authors:  G L Nelsestuen; S Kirkwood
Journal:  Biochim Biophys Acta       Date:  1970-12-16
  8 in total
  8 in total

Review 1.  Molecular genetics of nucleotide sugar interconversion pathways in plants.

Authors:  W D Reiter; G F Vanzin
Journal:  Plant Mol Biol       Date:  2001-09       Impact factor: 4.076

2.  Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi.

Authors:  Y Hashimoto; N Li; H Yokoyama; T Ezaki
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

3.  Partial reactions of D-glucose 6-phosphate-1L-myoinositiol 1-phosphate cyclase.

Authors:  J E Barnett; A Rasheed; D L Corina
Journal:  Biochem J       Date:  1973-01       Impact factor: 3.857

4.  Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.

Authors:  David J Timson; Steffen Lindert
Journal:  Gene       Date:  2013-05-31       Impact factor: 3.688

5.  Analysis of UDP-galactose 4'-epimerase mutations associated with the intermediate form of type III galactosaemia.

Authors:  J S Chhay; C A Vargas; T J McCorvie; J L Fridovich-Keil; D J Timson
Journal:  J Inherit Metab Dis       Date:  2008-01-14       Impact factor: 4.982

6.  BrUGE1 transgenic rice showed improved growth performance with enhanced drought tolerance.

Authors:  Sailila E Abdula; Hye Jung Lee; Joonki Kim; Marjohn C Niño; Yu-Jin Jung; Young-Chan Cho; Illsup Nou; Kwon-Kyoo Kang; Yong-Gu Cho
Journal:  Breed Sci       Date:  2016-03-01       Impact factor: 2.086

7.  Galactose epimerase deficiency: lessons from the GalNet registry.

Authors:  Britt Derks; Gerard T Berry; M Estela Rubio-Gozalbo; Didem Demirbas; Rodrigo R Arantes; Samantha Banford; Alberto B Burlina; Analía Cabrera; Ana Chiesa; M Luz Couce; Carlo Dionisi-Vici; Matthias Gautschi; Stephanie Grünewald; Eva Morava; Dorothea Möslinger; Sabine Scholl-Bürgi; Anastasia Skouma; Karolina M Stepien; David J Timson
Journal:  Orphanet J Rare Dis       Date:  2022-09-02       Impact factor: 4.303

8.  UDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.

Authors:  Veronika L Zinsser; Steffen Lindert; Samantha Banford; Elizabeth M Hoey; Alan Trudgett; David J Timson
Journal:  Parasitology       Date:  2014-08-15       Impact factor: 3.234
  8 in total

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