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Literature DB >> 4930387

Malformations of central nervous system and softness of local water supplies.

Abstract

The mean annual prevalence at birth of congenital malformations of the central nervous system for the three years 1964-6 in 48 local authority areas in South Wales was negatively correlated (r = -0.402, P<0.01) with estimates of the mean total hardness of the related water supplies.The mean annual perinatal mortality rate from anencephalus for the five years 1963-7 in 58 county boroughs in England and Wales was also negatively correlated with estimates of the mean total hardness (r = -0.220, P>0.05) and calcium content (r = -0.289, P<0.05) of the related water supplies.It is concluded that the relationship between these associations may well be secondary. Analytical epidemiological studies of the association are called for.

Entities: Chemical Disease

Mesh：

Substances：
Water
Calcium

Year: 1971 PMID： 4930387 PMCID： PMC1795729 DOI： 10.1136/bmj.2.5758.357

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

17 in total

1. SEASONAL VARIATION IN CONGENITAL ABNORMALITIES. PRELIMINARY REPORT OF A SURVEY CONDUCTED BY THE RESEARCH COMMITTEE OF COUNCIL OF THE COLLEGE OF GENERAL PRACTITIONERS.

Authors: B C SLATER; G I WATSON; J C MCDONALD
Journal: Br J Prev Soc Med Date: 1964-01

5. Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

Authors: J H Renwick
Journal: Br J Prev Soc Med Date: 1972-05

6. Area differences in prevalence of neural tube malformations in South Wales. A study of possible demographic determinants.

Authors: I D Richards; C J Roberts; S Lloyd
Journal: Br J Prev Soc Med Date: 1972-05

Malformations of central nervous system and softness of local water supplies.

1. SEASONAL VARIATION IN CONGENITAL ABNORMALITIES. PRELIMINARY REPORT OF A SURVEY CONDUCTED BY THE RESEARCH COMMITTEE OF COUNCIL OF THE COLLEGE OF GENERAL PRACTITIONERS.

2. Congenital malformations of the central nervous system in Scotland.

3. Genetics of anencephaly.

4. Seasonal incidence of congenital malformations of the central nervous system.

5. Changes in the incidence of neural-tube defects.

6. Mortality and hardness of water.

7. Mortality and hardness of local water-supplies.

8. Epidemilogy of stillbirths from congenital abnormalities in England and Wales, 1961-1966.

9. Anencephalus and the local water supply.

10. Unrecognised epidemic of anencephaly and spina bifida.

1. Comparison of the mineral content of tap water and bottled waters.

2. Lead levels in domestic water supplies and neural tube defects in Glasgow.

3. Trace elements in water and congenital malformations of the central nervous system in South Wales.

4. Soil and congenital malformations.

5. Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.

6. Area differences in prevalence of neural tube malformations in South Wales. A study of possible demographic determinants.

7. Anencephalus and maternal tea drinking: evidence for a possible association.

8. Anencephalus and water hardness in south-west Lancashire.

9. Neural tube malformations and trace elements in water.

10. Congenital malformations and the problem of their control.