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Literature DB >> 492449

Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain.

M Wollemann, A Szebeni, S Bajusz, L Gráf.

Abstract

Among opiatelike peptides, stimulatory as well as inhibitory effects are encountered on adenylate cyclase activity. These actions are dependent not only on the investigated brain region but also on the applied peptide. Met-enkephalin stimulates adenylate cyclase activity in the rat brain stem (D-Met2, Pro5)-enkephalinamide and beta-endorphin inhibited it, whereas all three peptides inhibited the activity of cortex. Naloxone antagonized the effects of the applied peptides in the presence of sodium chloride.

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Year: 1979 PMID： 492449 DOI： 10.1007/bf00964439

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

15 in total

1. Isolation of a COOH-terminal beta-lipotropin fragment (residues 61--91) with morphine-like analgesic activity from porcine pituitary glands.

Authors: L Gráf; E Barát; A Patthy
Journal: Acta Biochim Biophys Acad Sci Hung Date: 1976

1. Comparison of the effects of [leucine]enkephalin and angiotensin on hepatic carbohydrate and cyclic nucleotide metabolism.

Authors: S K Hothi; R P Leach; M A Titheradge
Journal: Biochem J Date: 1988-02-01 Impact factor: 3.857

1 in total

Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain.

1. Isolation of a COOH-terminal beta-lipotropin fragment (residues 61--91) with morphine-like analgesic activity from porcine pituitary glands.

2. Effect of morphine sulfate on adenylate cyclase and phosphodiesterase activities in rat corpus striatum.

3. Adrenocorticotropin in rat brain: immunocytochemical localization in cells and axons.

4. Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma X glioma hybrid cells.

5. Enkephalin and opiate narcotics increase cyclic GMP accumulation in slices of rat neostriatum.

6. Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.

7. A superactive antinociceptive pentapeptide, (D-Met2, Pro5)-enkephalinamide.

8. Endogenous opioid peptides: multiple agonists and receptors.

9. Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.

10. Opiate-dependent modulation of adenylate cyclase.

1. Comparison of the effects of [leucine]enkephalin and angiotensin on hepatic carbohydrate and cyclic nucleotide metabolism.