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Literature DB >> 4920799

Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.

B O Osuntokun, M J Langman, J Wilson, A Aladetoyinbo.

Abstract

The results are presented of a double-blind therapeutic trial of hydroxocobalamin and riboflavine in Nigerian patients suffering from a degenerative neuropathy. Although no benefit from either vitamin was demonstrated, this may reflect the inadequacy of the dosages used. The results are discussed in relation to the hypothesis that dietary cyanide and cyanogens are responsible, at least in part, for the occurrence of this disease in a malnourished population.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1970 PMID： 4920799 PMCID： PMC493545 DOI： 10.1136/jnnp.33.5.663

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

11 in total

1. THERAPEUTIC EFFECT OF VITAMIN B COMPLEX ON AN ATAXIC SYNDROME IN WESTERN NIGERIA.

Authors: G L MONEKOSSO; W G ANNAN; P H ASHBY
Journal: Trans R Soc Trop Med Hyg Date: 1964-09 Impact factor: 2.184

2. Leber's hereditary optic atrophy: some clinical and aetiological considerations.

Authors: J WILSON
Journal: Brain Date: 1963-06 Impact factor: 13.501

3. Chemical determination of vitamin B12. II. The quantitative isolation and colorimetric determination of millimicrogram quantities of cyanide.

Authors: G E BOXER; J C RICKARDS
Journal: Arch Biochem Date: 1951-02

4. Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease.

Authors: G L Monekosso; J Wilson
Journal: Lancet Date: 1966-05-14 Impact factor: 79.321

5. Relationship of a degenerative tropical neuropathy to diet: report of a field survey.

Authors: B O Osuntokun; G L Monekosso; J Wilson
Journal: Br Med J Date: 1969-03-01

6. An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.

Authors: B O Osuntokun
Journal: Brain Date: 1968-06 Impact factor: 13.501

7. Leber's hereditary optic atrophy: a possible defect of cyanide metabolism.

Authors: J Wilson
Journal: Clin Sci Date: 1965-12 Impact factor: 6.124

8. Metabolic inter-relationships between cyanide, thiocyanate and vitamin B 12 in smokers and non-smokers.

Authors: J Wilson; D M Matthews
Journal: Clin Sci Date: 1966-08 Impact factor: 6.124

9. Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency.

Authors: J Wilson; M J Langman
Journal: Nature Date: 1966-11-19 Impact factor: 49.962

10. New concept of critical steps in course of chronic debilitating neurologic disease in evaluation of therapeutic response; a longitudinal study of multiple sclerosis by quantitative evaluation of neurologic involvement and disability.

Authors: L ALEXANDER
Journal: AMA Arch Neurol Psychiatry Date: 1951-09

6 in total

Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.

1. THERAPEUTIC EFFECT OF VITAMIN B COMPLEX ON AN ATAXIC SYNDROME IN WESTERN NIGERIA.

2. Leber's hereditary optic atrophy: some clinical and aetiological considerations.

3. Chemical determination of vitamin B12. II. The quantitative isolation and colorimetric determination of millimicrogram quantities of cyanide.

4. Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease.

5. Relationship of a degenerative tropical neuropathy to diet: report of a field survey.

6. An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.

7. Leber's hereditary optic atrophy: a possible defect of cyanide metabolism.

8. Metabolic inter-relationships between cyanide, thiocyanate and vitamin B 12 in smokers and non-smokers.

9. Relation of sub-acute combined degeneration of the cord to vitamin B 12 deficiency.

10. New concept of critical steps in course of chronic debilitating neurologic disease in evaluation of therapeutic response; a longitudinal study of multiple sclerosis by quantitative evaluation of neurologic involvement and disability.

1. Persistence of tropical ataxic neuropathy in a Nigerian community.

2. Role of vegetarianism, smoking, and hydroxocobalamin in optic neuritis.

Review 3. Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.

4. Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.

5. Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.

6. Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.