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Literature DB >> 4360398

Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.

B O Osuntokun, M J Langman, J Wilson, A O Adeuja.

Abstract

Chronic cyanide intoxication of dietary origin and riboflavine deficiency are believed to be major aetiological factors in Nigerian tropical ataxic neuropathy. The results are presented of a double-blind controlled therapeutic trial of combinations of large doses of hydroxocobalamin and cystine as cyanide binding agents together with riboflavine or placebos in Nigerian patients suffering from the tropical ataxic neuropathy. No clinical benefit was demonstrable with any of the treatments.

Entities: Chemical Disease Species

Mesh：

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Year: 1974 PMID： 4360398 PMCID： PMC494569 DOI： 10.1136/jnnp.37.1.102

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

7 in total

1. Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease.

Authors: G L Monekosso; J Wilson
Journal: Lancet Date: 1966-05-14 Impact factor: 79.321

2. Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.

Authors: B O Osuntokun; M J Langman; J Wilson; A Aladetoyinbo
Journal: J Neurol Neurosurg Psychiatry Date: 1970-10 Impact factor: 10.154

3. Epidemiology of tropical nutritional neuropathy in Nigerians.

Authors: B O Osuntokun
Journal: Trans R Soc Trop Med Hyg Date: 1971 Impact factor: 2.184

4. Biochemical studies in Tanzanian patients with ataxic tropical neuropathy.

Authors: W J Makene; J Wilson
Journal: J Neurol Neurosurg Psychiatry Date: 1972-02 Impact factor: 10.154

5. Relationship of a degenerative tropical neuropathy to diet: report of a field survey.

Authors: B O Osuntokun; G L Monekosso; J Wilson
Journal: Br Med J Date: 1969-03-01

6. An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.

Authors: B O Osuntokun
Journal: Brain Date: 1968-06 Impact factor: 13.501

7. Plasma amino-acids in the Nigerian nutritional ataxic neuropathy.

Authors: B O Osuntokun; J E Durowoju; H McFarlane; J Wilson
Journal: Br Med J Date: 1968-09-14

7 in total

4 in total

Controlled trial of combinations of hydroxocobalamin-cystine and riboflavine-cystine, in Nigerian ataxic neuropathy.

1. Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease.

2. Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy.

3. Epidemiology of tropical nutritional neuropathy in Nigerians.

4. Biochemical studies in Tanzanian patients with ataxic tropical neuropathy.

5. Relationship of a degenerative tropical neuropathy to diet: report of a field survey.

6. An ataxic neuropathy in Nigeria. A clinical, biochemical and electrophysiological study.

7. Plasma amino-acids in the Nigerian nutritional ataxic neuropathy.

1. Persistence of tropical ataxic neuropathy in a Nigerian community.

Review 2. Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.

3. Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community.

4. Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.