Literature DB >> 4920091

Mapping of a human genetic regulator element by somatic cell genetic analysis.

R J Klebe, T Chen, R H Ruddle.   

Abstract

The ES-2 esterase is a kidney-associated esterase and is expressed in a cloned mouse renal adenocarcinoma cell line. Somatic cell hybridization of the mouse renal adenocarcinoma with either mouse or human fibroblasts leads to the marked reduction of ES-2 esterase titer. The extinction of ES-2 esterase activity in mousexhuman hybrids is reversible. Extinction correlates with the presence of the human C(10) chromosome in the somatic cell hybrids; whereas reexpression of the ES-2 esterase is observed in hybrids which have lost C(10). Thus, the proposed regulator element involved is probably structurally linked to C(10); however, linkage to a member of the D or G groups cannot be completely excluded.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 4920091      PMCID： PMC335809          DOI： 10.1073/pnas.66.4.1220

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Hormone-producing cultures of adrenal and pituitary tumor origin.

Authors:  V BUONASSISI; G SATO; A I COHEN
Journal:  Proc Natl Acad Sci U S A       Date:  1962-07-15       Impact factor: 11.205

2.  Genetic regulatory mechanisms in the synthesis of proteins.

Authors:  F JACOB; J MONOD
Journal:  J Mol Biol       Date:  1961-06       Impact factor: 5.469

3.  Histochemical demonstration of enzymes separated by zone electrophoresis in starch gels.

Authors:  R L HUNTER; C L MARKERT
Journal:  Science       Date:  1957-06-28       Impact factor: 47.728

4.  Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2.

Authors:  F H Ruddle; T B Shows; T H Roderick
Journal:  Genetics       Date:  1969-06       Impact factor: 4.562

5.  Inherited variations in human phosphohexose isomerase.

Authors:  J C Detter; P O Ways; E R Giblett; M A Baughan; D A Hopkinson; S Povey; H Harris
Journal:  Ann Hum Genet       Date:  1968-05       Impact factor: 1.670

6.  Properties and uses of human-mouse hybrid cell lines.

Authors:  Y Matsuya; H Green; C Basilico
Journal:  Nature       Date:  1968-12-21       Impact factor: 49.962

7.  Function of the lactate dehydrogenase B gene in mouse erythrocytes: evidence for control by a regulatory gene.

Authors:  T B Shows; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

8.  The influence of collagen on the development of muscle clones.

Authors:  S D Hauschka; I R Konigsberg
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

9.  Hybridization of a malignant melanoma cell line with L cells in vitro.

Authors:  S Silagi
Journal:  Cancer Res       Date:  1967-11       Impact factor: 12.701

10.  Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes.

Authors:  M C Weiss; H Green
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205
View more
  32 in total

1.  Simian virus 40-related antigens in three human meningiomas with defined chromosome loss.

Authors:  A F Weiss; R Portmann; H Fischer; J Simon; K D Zang
Journal:  Proc Natl Acad Sci U S A       Date:  1975-02       Impact factor: 11.205

2.  What history tells us XII. Boris Ephrussi's continuing efforts to create a "genetics of differentiation".

Authors:  Michel Morange
Journal:  J Biosci       Date:  2008-03       Impact factor: 1.826

3.  Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.

Authors:  C Petit; J Levilliers; M O Ott; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

Review 4.  Use of somatic cell hybrids for analysis of the differentiated state.

Authors:  F M Davis; E A Adelberg
Journal:  Bacteriol Rev       Date:  1973-06

5.  Expression of differentiated functions in hepatoma cell hybrids: high frequency of induction of mouse albumin production in rat hepatoma-mouse lymphoblast hybrids.

Authors:  S E Malawista; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

Review 6.  Utilization of somatic cell hybrids for genetic studies in man.

Authors:  K H Grzeschik
Journal:  Humangenetik       Date:  1973

7.  Genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeB gene.

Authors:  F T Kao; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

8.  Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 .

Authors:  T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

9.  Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes.

Authors:  M C Weiss; M Chaplain
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

10.  Human beta-D-N-acetylhexosaminidases A and B: expression and linkage relationships in somatic cell hybrids.

Authors:  P A Lalley; M C Rattazzi; T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.