Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The abrogation of sheep erythrocyte tolerance in rats by means of the transfer of allogeneic lymphocytes.

Literature DB >> 4919143

The abrogation of sheep erythrocyte tolerance in rats by means of the transfer of allogeneic lymphocytes.

Abstract

Whereas the transfer of lymphocytes from normal syngeneic donors fails to abrogate tolerance of sheep erythrocytes in rats, lymphocytes from allogeneic donors are effective. When tolerance is abrogated in this situation, the hemolysin-forming cells are predominantly of host origin. Immunological interaction between transfused lymphocytes and host cells is a prerequisite for the abrogation of tolerance. From the time required for abrogation to occur after transfer of the allogeneic cells, it is suggested that tolerance of sheep erythrocytes in rats represents the repression of a specific reactivity in cells rather than the elimination or irreversible inactivation of reactive cells. This explanation implies the existence of specifically tolerant cells.

Entities: Species

Mesh：

Year: 1970 PMID： 4919143 PMCID： PMC2138870 DOI： 10.1084/jem.132.5.916

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

5 in total

4. The immunological capacity of lymphocytes from normal donors after their transfer to rats tolerant of sheep erythrocytes.

Authors: P J McCullagh
Journal: Aust J Exp Biol Med Sci Date: 1970-08

5. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.

Authors: G F Mitchell; J F Miller
Journal: J Exp Med Date: 1968-10-01 Impact factor: 14.307

5 in total

18 in total

1. Regulatory substances produced by lymphocytes : I. Inhibitor of DNA synthesis in the rat.

Authors: Y Namba; B H Waksman
Journal: Inflammation Date: 1975-03 Impact factor: 4.092

2. Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism.

Authors: J Cihak; F Lehmann-Grube
Journal: Immunology Date: 1978-02 Impact factor: 7.397

6. Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction against I-A and I-J-region differences, respectively.

Authors: R M Zinkernagel
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

10. Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.

Authors: D H Katz; J M Davie; W E Paul; B Benacerraf
Journal: J Exp Med Date: 1971-07-01 Impact factor: 14.307

The abrogation of sheep erythrocyte tolerance in rats by means of the transfer of allogeneic lymphocytes.

1. The origin of antibody forming cells from lymphocytes.

2. Further improvements in the plaque technique for detecting single antibody-forming cells.

3. The transfer of immunological competence to rats tolerant of sheep erythrocytes with lymphocytes from normal rats.

4. The immunological capacity of lymphocytes from normal donors after their transfer to rats tolerant of sheep erythrocytes.

5. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.

1. Regulatory substances produced by lymphocytes : I. Inhibitor of DNA synthesis in the rat.

2. Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism.

Review 3. Interactions of thymus-dependent and bone-marrow-derived lymphocytes in immunological tolerance.

4. Reversibility of high dose unresponsiveness to concanavalin A in thymus lymphocytes.

5. T-cell regulation of T-cell responses to antigen.

6. Activation or suppression of bactericidal activity of macrophages during a graft-versus-host reaction against I-A and I-J-region differences, respectively.

7. Regulation of immune response to SRBC: suppressor cell activity induced by soluble fraction of antigen.

8. Rapid breaking of tolerance against Escherichia coli lipopolysaccharide in vivo and in vitro.

9. Significance of cell interactions in production of graft versus host splenomegaly.

10. Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.