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Literature DB >> 4914568

Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12.

Abstract

Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.

Entities: Chemical Species

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Year: 1970 PMID： 4914568 PMCID： PMC248097 DOI： 10.1128/jb.103.2.417-421.1970

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

1. Limited thymidine uptake in Escherichia coli due to an inducible thymidine phosphorylase.

Authors: M RACHMELER; J GERHART; J ROSNER
Journal: Biochim Biophys Acta Date: 1961-04-29

2. Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure.

Authors: K K TSUBOI; P B HUDSON
Journal: J Biol Chem Date: 1957-02 Impact factor: 5.157

3. Incorporation of 5-bromodeoxyuridine into DNA of wild type Escherichia coli and its use for the enrichment of auxotrophic mutants.

Authors: A Rosner; E Yagil
Journal: Mol Gen Genet Date: 1970

4. Specificity and efficiency of thymidine incorporation in Escherichia coli lacking thymidine phosphorylase.

Authors: W L Fangman
Journal: J Bacteriol Date: 1969-09 Impact factor: 3.490

5. A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli.

Authors: S I Ahmad; R H Pritchard
Journal: Mol Gen Genet Date: 1969-08-15

6. Characteristics of the deo operon: role in thymine utilization and sensitivity to deoxyribonucleosides.

Authors: M S Lomax; G R Greenberg
Journal: J Bacteriol Date: 1968-08 Impact factor: 3.490

7. The effect of nucleosides on the phosphorolysis of thymidine by normal and phage-infected cells of E. coli.

Authors: J Doskocil; V Paces
Journal: Biochem Biophys Res Commun Date: 1968-01-25 Impact factor: 3.575

8. Thymidine breakdown and thymine uptake in different mutants of Escherichia coli.

Authors: A Munch-Petersen
Journal: Biochim Biophys Acta Date: 1967-06-20

9. Mutant bacteria showing efficient utilization of thymidine.

Authors: W L Fangman; A Novick
Journal: J Bacteriol Date: 1966-06 Impact factor: 3.490

10. Thymidine and thymine incorporation into deoxyribonucleic acid: inhibition and repression by uridine of thymidine phosphorylase of Escherichia coli.

Authors: D R Budman; A B Pardee
Journal: J Bacteriol Date: 1967-11 Impact factor: 3.490

13 in total

5. R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.

Authors: R J Pinney; K Bremer; J T Smith
Journal: Mol Gen Genet Date: 1974

Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12.

1. Limited thymidine uptake in Escherichia coli due to an inducible thymidine phosphorylase.

2. Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure.

3. Incorporation of 5-bromodeoxyuridine into DNA of wild type Escherichia coli and its use for the enrichment of auxotrophic mutants.

4. Specificity and efficiency of thymidine incorporation in Escherichia coli lacking thymidine phosphorylase.

5. A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli.

6. Characteristics of the deo operon: role in thymine utilization and sensitivity to deoxyribonucleosides.

7. The effect of nucleosides on the phosphorolysis of thymidine by normal and phage-infected cells of E. coli.

8. Thymidine breakdown and thymine uptake in different mutants of Escherichia coli.

9. Mutant bacteria showing efficient utilization of thymidine.

10. Thymidine and thymine incorporation into deoxyribonucleic acid: inhibition and repression by uridine of thymidine phosphorylase of Escherichia coli.

1. Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells.

2. Regulatory mutants of the deo regulon in Salmonella typhimurium.

3. Efficiency of thymidine incorporation in Escherichia coli B-r as a function of growth rate.

4. Temperature-sensitive mutant of Bacillus subtilis that accumulates membrane-associated protein inclusions.

5. R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.

6. Transfection of Escherichia coli spheroplasts with a bacteriophage Mu DNA-protein complex.

7. Partial purification and properties of an exonuclease inhibitor induced by bacteriophage Mu-1.

8. Degradation of thymidine by Lactobacillus acidophilus.

9. Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides.

10. Degree of participation of exogenous thymidine in the overall deoxyribonucleic acid synthesis in Escherichia coli.