Literature DB >> 49093

[First clinical results of radiotherapy following partial synchronization by bleomycin].

M Wannenmacher, E Esser, J Schumann.   

Abstract

On the Ehrlich-ascites tumor and on the solide Ehrlich carcinoma of the mouse, bleomycin causes a large fixation in the (G2+M)-phase of the cell cycle of the tumor cells. Even in certain human solide tumors, after the application of bleomycin in a predetermined period an increase of the G2 portion of the proliferating cells can be observed. By individual control which can be peraformed rapidly and with high accuracy by impulse cytophotometry, this partial synchronisation effect can be used for radiotherapy.

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Year:  1975        PMID: 49093

Source DB:  PubMed          Journal:  Strahlentherapie        ISSN: 0039-2073


  3 in total

Review 1.  [Present state in synchronization therapy of malignant tumors and acute leukemias (author's transl)].

Authors:  H Sauer; W Wilmanns
Journal:  Klin Wochenschr       Date:  1976-03-01

2.  Radiosensitivity and recovery of mouse L cells during the cell cycle.

Authors:  J Fidorra; W A Linden
Journal:  Radiat Environ Biophys       Date:  1977-12-12       Impact factor: 1.925

3.  [Partial synchronization of tumor cells in vivo with hydroxyurea (author's transl)].

Authors:  R Hartenstein; K Pfundmair; K Possinger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977
  3 in total

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