Literature DB >> 490172

An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae).

J M Cassady, N Ojima, C Chang, J L McLaughlin.   

Abstract

Extracts of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. were fractionated based on in vivo activity in mice in the P-388 lymphocytic leukemia system. Activity in ethanol extracts was concentrated in the chloroform partition fraction, which was further resolved by chromatography on silica gel. The known coumarins, micromelin and scopoletin, were crystallized from the active fractions and demonstrated to have antitumor activities. Micromelin was converted to the corresponding butenolide (deoxymicromelin) which was inactive in the 9KB assay.

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Year:  1979        PMID： 490172     DOI： 10.1021/np50003a005

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  New guaiane sesquiterpenes and furanocoumarins from Notopterygium incisum.

Authors:  Shi-Biao Wu; Yun Zhao; Hui Fan; Ying-He Hu; Mark T Hamann; Jiang-Nan Peng; Courtney M Starks; Mark O'Neil-Johnson; Jin-Feng Hu
Journal:  Planta Med       Date:  2008-11-07       Impact factor: 3.352

2.  7-Hy-droxy-6-meth-oxy-2H-chromen-2-one.

Authors:  Hooi-Kheng Beh; Zhari Ismail; Mohd Zaini Asmawi; Wan-Sin Loh; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-31

3.  Two new coumarins from Micromelum falcatum with cytotoxicity and brine shrimp larvae toxicity.

Authors:  Xiongming Luo; Weihong He; Hao Yin; Qingxin Li; Qiao Liu; Yongzhong Huang; Si Zhang
Journal:  Molecules       Date:  2012-06-06       Impact factor: 4.411

Review 4.  Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use.

Authors:  Anik Boudreau; Allison J Richard; Innocence Harvey; Jacqueline M Stephens
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-08       Impact factor: 5.555

5.  (1R,3R,4R,6S)-4-(7-Meth-oxy-2-oxo-2H-chromen-6-yl)-1-methyl-3,6-dioxa-bicyclo-[3.1.0]hexan-2-yl acetate.

Authors:  Wong Phakhodee; Surat Laphookhieo; Timothy John Prior; Apinpus Rujiwatra
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24

6.  Rapid identification of coumarins from Micromelum falcatum by UPLC-HRMS/MS and targeted isolation of three new derivatives.

Authors:  Eirini Kouloura; Eirini Danika; Sothea Kim; Mélanie Hoerlé; Muriel Cuendet; Maria Halabalaki; Leandros A Skaltsounis
Journal:  Molecules       Date:  2014-09-19       Impact factor: 4.411

7.  Synthesis and Acaricidal Activities of Scopoletin Phenolic Ether Derivatives: QSAR, Molecular Docking Study and in Silico ADME Predictions.

Authors:  Jinxiang Luo; Ting Lai; Tao Guo; Fei Chen; Linli Zhang; Wei Ding; Yongqiang Zhang
Journal:  Molecules       Date:  2018-04-24       Impact factor: 4.411
  7 in total

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