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Literature DB >> 4895537

Recessive lethals: a new class of nonsense suppressors in Escherichia coli.

Abstract

Two new nonsense suppressors in Escherichia coli were found in partial diploids carrying F'14 and were shown to be on the episome. These suppressors can exist only in cells which also contain the su(-) allele, i.e., su(+)/su(-) heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal. Su7, an amber suppressor, has an efficiency of 76 per cent and su8, an ochre suppressor, an efficiency of 4 per cent.

Entities: Chemical Disease Species

Mesh：

Year: 1969 PMID： 4895537 PMCID： PMC223577 DOI： 10.1073/pnas.63.2.392

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

1. GENETIC INSTABILITY IN ESCHERICHIA COLI.

Authors: N M SCHWARTZ
Journal: J Bacteriol Date: 1965-03 Impact factor: 3.490

2. ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12.

Authors: A J CLARK; A D MARGULIES
Journal: Proc Natl Acad Sci U S A Date: 1965-02 Impact factor: 11.205

3. IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI.

Authors: K A STACEY; E SIMSON
Journal: J Bacteriol Date: 1965-08 Impact factor: 3.490

4. Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of bacteriophage lambda.

Authors: W ARBER; D DUSSOIX
Journal: J Mol Biol Date: 1962-07 Impact factor: 5.469

5. Selecting bacterial mutants by the penicillin method.

Authors: L GORINI; H KAUFMAN
Journal: Science Date: 1960-02-26 Impact factor: 47.728

6. Acetylornithinase of Escherichia coli: partial purification and some properties.

Authors: H J VOGEL; D M BONNER
Journal: J Biol Chem Date: 1956-01 Impact factor: 5.157

7. THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

Authors: Y Hirota
Journal: Proc Natl Acad Sci U S A Date: 1960-01 Impact factor: 11.205

8. Instability of a missense suppressor resulting from a duplication of genetic material.

Authors: C W Hill; J Foulds; L Soll; P Berg
Journal: J Mol Biol Date: 1969-02-14 Impact factor: 5.469

9. Revertant instability in Escherichia coli. II. Genetic studies.

Authors: N M Schwartz
Journal: Genetics Date: 1967-11 Impact factor: 4.562

10. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor.

Authors: M R Capecchi; G N Gussin
Journal: Science Date: 1965-07-23 Impact factor: 47.728

34 in total

1. Isolation and characterization of lambda transducing bacteriophages for the su1+ (supD minus) amber suppressor of Escherichia coli.

Authors: D A Steege; B Low
Journal: J Bacteriol Date: 1975-04 Impact factor: 3.490

6. Cloning of the replication gene P of bacteriophage lambda: effects of increased P-protein synthesis on cellular and phage DNA replication.

Authors: J Klinkert; A Klein
Journal: Mol Gen Genet Date: 1979-03-20

7. Phenylalanine and tyrosine biosynthesis in Escherichia coli K-12: mutants derepressed for 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (phe), 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (tyr), chorismate mutase T-prephenate dehydrogenase, and transaminase A.

Authors: S W Im; H Davidson; J Pittard
Journal: J Bacteriol Date: 1971-10 Impact factor: 3.490

Recessive lethals: a new class of nonsense suppressors in Escherichia coli.

1. GENETIC INSTABILITY IN ESCHERICHIA COLI.

2. ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12.

3. IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI.

4. Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of bacteriophage lambda.

5. Selecting bacterial mutants by the penicillin method.

6. Acetylornithinase of Escherichia coli: partial purification and some properties.

7. THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

8. Instability of a missense suppressor resulting from a duplication of genetic material.

9. Revertant instability in Escherichia coli. II. Genetic studies.

10. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor.

1. Isolation and characterization of lambda transducing bacteriophages for the su1+ (supD minus) amber suppressor of Escherichia coli.

2. Chloroplast heteroplasmicity is stabilized by an amber-suppressor tryptophan tRNA(CUA).

3. cheA, cheB, and cheC genes of Escherichia coli and their role in chemotaxis.

Review 4. Recalibrated linkage map of Escherichia coli K-12.

Review 5. Transfer ribonucleic acid-mediated suppression of termination codons in Escherichia coli.

6. Cloning of the replication gene P of bacteriophage lambda: effects of increased P-protein synthesis on cellular and phage DNA replication.

7. Phenylalanine and tyrosine biosynthesis in Escherichia coli K-12: mutants derepressed for 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (phe), 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (tyr), chorismate mutase T-prephenate dehydrogenase, and transaminase A.

8. Defined set of cloned termination suppressors: in vivo activity of isogenetic UAG, UAA, and UGA suppressor tRNAs.

9. Isolation of nonsense suppressor mutants in Pseudomonas.

10. Regulation of tyrosine and phenylalanine biosynthesis in Escherichia coli K-12: properties of the tyrR gene product.