Carbohydrate accumulation and metabolism in Escherichia coli: the close linkage and chromosomal location of ctr mutations.

Six pleiotropic ctr mutations of Escherichia coli, affecting the ability to utilize 10 carbohydrates, were found to be closely linked to one another and to the mutation of strain MM6 causing lack of enzyme 1 of the phosphotransferase system. These mutations are located at 46 to 47 min on the E. coli map. Preliminary biochemical evidence indicates that the ctr mutants also lack enzyme 1, although they have a different phenotype from MM6.