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Literature DB >> 13701685

Damage by visible light to the acridine orange--DNA complex.

D FREIFELDER, P F DAVISON, E P GEIDUSCHEK.

Abstract

Salmon DNA has been irradiated with visible light in the presence of acridine orange. If the dye is bound to the DNA, there results: (a) a decrease in sedimentation coefficient, (b) a lowering of viscosity, and (c) a decrease in the thermal denaturation temperature. CsCl banding experiments show that the first two effects reflect depolymerization of the DNA. Depolymerization apparently occurs by single-strand scission although some double-strand scission is not excluded. The destabilization of secondary structure results probably from chemical attack on the components of the individual strands.

Entities: Chemical

Keywords: ACRIDINES/chemistry; DESOXYRIBONUCLEIC ACID/chemistry; LIGHT

Mesh：

Substances：

Year: 1961 PMID： 13701685 PMCID： PMC1366317 DOI： 10.1016/s0006-3495(61)86897-5

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

9 in total

1. Effect of nitric oxide on the production of chromosomal aberrations by x-rays.

Authors: B A KIHLMAN
Journal: Exp Cell Res Date: 1959-06 Impact factor: 3.905

2. Distribution of proflavin-induced mutations in the genetic fine structure.

Authors: S BRENNER; S BENZER; L BARNETT
Journal: Nature Date: 1958-10-11 Impact factor: 49.962

3. Inactivation by visible light of yeast sensitized by a nucleic acid fluorochrome.

Authors: D FREIFELDER; R B URETZ
Journal: Nature Date: 1960-05-28 Impact factor: 49.962

4. Complex formation between adenine oligonucleotides and polyuridylic acid.

Authors: M N LIPSETT; L A HEPPEL; D F BRADLEY
Journal: Biochim Biophys Acta Date: 1960-06-17

5. Inhibition and activation of polynucleotide phosphorylase through the formation of complexes between acridine orange and polynucleotides.

Authors: R F BEERS; D D HENDLEY; R F STEINER
Journal: Nature Date: 1958-07-26 Impact factor: 49.962

6. STRAND SEPARATION AND SPECIFIC RECOMBINATION IN DEOXYRIBONUCLEIC ACIDS: PHYSICAL CHEMICAL STUDIES.

Authors: P Doty; J Marmur; J Eigner; C Schildkraut
Journal: Proc Natl Acad Sci U S A Date: 1960-04 Impact factor: 11.205

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Authors: R Rolfe; M Meselson
Journal: Proc Natl Acad Sci U S A Date: 1959-07 Impact factor: 11.205

8. THE PROPERTIES OF SONIC FRAGMENTS OF DEOXYRIBOSE NUCLEIC ACID.

Authors: P Doty; B B McGill; S A Rice
Journal: Proc Natl Acad Sci U S A Date: 1958-05 Impact factor: 11.205

9. Similarity of the structure of DNA from a variety of sources.

Authors: L D HAMILTON; R K BARCLAY; M H WILKINS; G L BROWN; H R WILSON; D A MARVIN; H EPHRUSSI-TAYLOR; N S SIMMONS
Journal: J Biophys Biochem Cytol Date: 1959-05-25

9 in total

22 in total

1. INTERACTION OF NUCLEIC ACIDS, II. CHEMICAL LINKAGE OF THE CARCINOGEN 3,4-BENZPYRENE TO DNA INDUCED BY PHOTORADIATION.

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Journal: Proc Natl Acad Sci U S A Date: 1964-02 Impact factor: 11.205

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Authors: D FREIFELDER; P F DAVISON
Journal: Biophys J Date: 1963-01 Impact factor: 4.033

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Authors: Y HOTTA; H STERN
Journal: Proc Natl Acad Sci U S A Date: 1963-06 Impact factor: 11.205

4. Dye-sensitized photoinactivation of yeast in relation to the x-ray oxygen effect.

Authors: R B URETZ; R H HAYNES
Journal: Proc Natl Acad Sci U S A Date: 1962-10-15 Impact factor: 11.205

5. An introduction to transcription and gene regulation.

Authors: E Peter Geiduschek
Journal: J Biol Chem Date: 2010-05-28 Impact factor: 5.157

6. Purification and staining of intact yeast DNA chromosomes and real-time observation of their migration during gel electrophoresis.

Authors: S Gurrieri; C Bustamante
Journal: Biochem J Date: 1997-08-15 Impact factor: 3.857

7. Real-time imaging of the reorientation mechanisms of YOYO-labelled DNA molecules during 90 degrees and 120 degrees pulsed field gel electrophoresis.

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Journal: Nucleic Acids Res Date: 1996-12-01 Impact factor: 16.971