Literature DB >> 488705

Mutations of Chinese hamster somatic cells from 2-deoxygalactose sensitivity to resistance.

J M Claverie, A C de Souza, J P Thirion.   

Abstract

In Chinese hamster somatic cells, the spontaneous change of phenotype from 2-deoxygalactose sensitivity to resistance was studied using fluctuation test experiments à la Luria and Delbrück (1943) for four Chinese hamster cell strains derived from V79. The results are consistent with true mutational events. The mutation rates are in the range of 1 to 3.5 X 10(-5) per cell per generation. The relationship between the 2-deoxyglactose resistance and the galactokinase markers is discussed.

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Year:  1979        PMID: 488705      PMCID: PMC1213976     

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  8 in total

1.  Observations on the chromosomes of Chinese hamster cells in tissue culture.

Authors:  D K FORD; G YERGANIAN
Journal:  J Natl Cancer Inst       Date:  1958-08       Impact factor: 13.506

2.  Mutations of Bacteria from Virus Sensitivity to Virus Resistance.

Authors:  S E Luria; M Delbrück
Journal:  Genetics       Date:  1943-11       Impact factor: 4.562

3.  Galactokinase mutants of Chinese hamster somatic cells resistant to 2-deoxygalactose.

Authors:  J P Thirion; D Banville; H Noel
Journal:  Genetics       Date:  1976-05       Impact factor: 4.562

4.  Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.

Authors:  O W McBride; J W Burch; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

5.  Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase.

Authors:  G E Jones; P A Sargent
Journal:  Cell       Date:  1974-05       Impact factor: 41.582

6.  Mammalian cell genetics. I. Selection and characterization of mutations auxotrophic for L-glutamine or resistant to 8-azaguanine in Chinese hamster cells in vitro.

Authors:  E H Chu; P Brimer; K B Jacobson; E V Merriam
Journal:  Genetics       Date:  1969-06       Impact factor: 4.562

7.  The isolation and preliminary characterization of somatic cell mutants resistant to the protein synthesis inhibitor-emetine.

Authors:  R S Gupta; L Siminovitch
Journal:  Cell       Date:  1976-10       Impact factor: 41.582

8.  Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis.

Authors:  R S Gupta; D Y Chan; L Siminovitch
Journal:  Cell       Date:  1978-08       Impact factor: 41.582

  8 in total
  1 in total

1.  Immunological and genetic characterization of 2-deoxygalactose-resistant, galactokinase-deficient mutants of Chinese hamster cells: evidence for structural mutations at the galK locus.

Authors:  B Talbot; C A de Souza; D Banville; J P Thirion
Journal:  Mol Cell Biol       Date:  1984-11       Impact factor: 4.272

  1 in total

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