Literature DB >> 4886043

The role of the platelet in the generalized Shwartzman reaction.

W Margaretten, D G McKay.   

Abstract

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.

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Year:  1969        PMID： 4886043      PMCID： PMC2138615          DOI： 10.1084/jem.129.3.585

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  9 in total

1.  Morphology and enumeration of human blood platelets.

Authors:  G BRECHER; E P CRONKITE
Journal:  J Appl Physiol       Date:  1950-12       Impact factor: 3.531

2.  Platelet factor 3 and the generalized Shwartzman reaction.

Authors:  G Müller-Berghaus; D Goldfinger; W Margaretten; D G McKay
Journal:  Thromb Diath Haemorrh       Date:  1967-12-31

3.  Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet factor 3.

Authors:  F Rodríguez-Erdmann
Journal:  Blood       Date:  1965-11       Impact factor: 22.113

4.  PLATELETS AND THE SHWARTZMAN PHENOMENON.

Authors:  J LEVIN; L E CLUFF
Journal:  J Exp Med       Date:  1965-02-01       Impact factor: 14.307

5.  Antigen-antibody reaction in the pathogenesis of bilateral renal cortical necrosis.

Authors:  L LEE
Journal:  J Exp Med       Date:  1963-03-01       Impact factor: 14.307

6.  Alterations in the blood coagulation system induced by bacterial endotoxin. I. In vivo (generalized Shwartzman reaction).

Authors:  D G McKAY; S S SHAPIRO
Journal:  J Exp Med       Date:  1958-03-01       Impact factor: 14.307

7.  Studies on the generalized Shwartzman reaction. IV. Prevention of the local and generalized Shwartzman reactions with heparin.

Authors:  R A GOOD; L THOMAS
Journal:  J Exp Med       Date:  1953-06       Impact factor: 14.307

8.  Effects of bacterial endotoxin on rabbit platelets. II. Enhancement of platelet factor 3 activity in vitro and in vivo.

Authors:  H I HOROWITZ; R M DES PREZ; E W HOOK
Journal:  J Exp Med       Date:  1962-11-01       Impact factor: 14.307

9.  Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon.

Authors:  L THOMAS; R A GOOD
Journal:  J Exp Med       Date:  1952-12       Impact factor: 14.307
  9 in total
  14 in total

1.  Effects of intravascular clotting on the activation of the complement system: The role of the platelet.

Authors:  S Kalowski; E L Howes; W Margaretten; D G McKay
Journal:  Am J Pathol       Date:  1975-03       Impact factor: 4.307

2.  Electron microscopic observations of the kidney in the generalized Shwartzman reaction.

Authors:  T Watanabe; K Tanaka
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1977-06-23

3.  Accumulation of platelets at acute inflammatory sites [proceedings].

Authors:  J P Bolam; M J Smith
Journal:  Br J Pharmacol       Date:  1977-09       Impact factor: 8.739

4.  The effect of leukocyte and platelet transfusion on the activation of intravascular coagulation by endotoxin in granulocytopenic and thrombocytopenic rabbits.

Authors:  E Bohn; G Müller-Berghaus
Journal:  Am J Pathol       Date:  1976-08       Impact factor: 4.307

Review 5.  The effects of bacterial endotoxins on host mediation systems. A review.

Authors:  D C Morrison; R J Ulevitch
Journal:  Am J Pathol       Date:  1978-11       Impact factor: 4.307

6.  The participation of the platelet in the vascular response to endotoxemia in the rabbit eye.

Authors:  E L Howes; D G McKay; W Margaretten
Journal:  Am J Pathol       Date:  1973-01       Impact factor: 4.307

7.  The requirement for platelets in the active Arthus reaction.

Authors:  W Margaretten; D G McKay
Journal:  Am J Pathol       Date:  1971-08       Impact factor: 4.307

8.  Heterophile antibodies and tissue injury. 1. Ultrastructure of pulmonary vascular lesions produced by Forssman antiserum in guinea-pigs.

Authors:  N S Taichman; M Creighton; A Stephenson; C C Tsai
Journal:  Immunology       Date:  1972-01       Impact factor: 7.397

9.  Heterophile antibodies and tissue injury. 3. A role for platelets in the development of lethal vascular injury during Forssman shock in guinea pigs.

Authors:  C C Tsai; N S Taichman; W H Pulver; E Schönbaum
Journal:  Am J Pathol       Date:  1973-08       Impact factor: 4.307

10.  Role of platelets in the pathogenesis of canine endotoxin shock.

Authors:  A H From; J S Fong; T Chiu; R A Good
Journal:  Infect Immun       Date:  1976-06       Impact factor: 3.441
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