Literature DB >> 488282

The localization of [3H]-desipramine in central nerve terminals studied with electron microscope autoradiography and subcellular fractionation.

Z Yavin, A Biegon, R Hofstein, D Samuel.   

Abstract

The cellular and subcellular distribution of [3H]-desipramine (DMI) in rat brain was studied by electron microscope (EM) autoradiography and by subcellular fractionation. A considerable proportion of label was found to be bound to the membranes of presynaptic nerve terminals, as well as to sites inside those terminals.

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Year:  1979        PMID： 488282     DOI： 10.1007/bf01963295

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  The nature of (3H)imipramine binding to synaptosomes.

Authors:  P F Hunt; M H Kannengiesser; J P Raynaud
Journal:  Biochem Pharmacol       Date:  1975-03-15       Impact factor: 5.858

2.  Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain.

Authors:  D C U'Prichard; D A Greenberg; P P Sheehan; S H Snyder
Journal:  Science       Date:  1978-01-13       Impact factor: 47.728

3.  Isolation of plasma membranes from rat brain.

Authors:  L S Wolfe; I G Morgan; G Gombos
Journal:  Biochim Biophys Acta       Date:  1971-09-14

4.  Analysis of the fine structure of the dopaminergic nigrostriatal projection by electron microscopic autoradiography.

Authors:  T Hattori; H C Fibiger; P L McGeer; L Maler
Journal:  Exp Neurol       Date:  1973-12       Impact factor: 5.330

Review 5.  The interactions of tricyclic antidepressants with the biogenic amine uptake systems in the central nervous system.

Authors:  A S Horn
Journal:  Postgrad Med J       Date:  1976       Impact factor: 2.401

6.  Brain histamine receptors as targets for antidepressant drugs.

Authors:  P D Kanof; P Greengard
Journal:  Nature       Date:  1978-03-23       Impact factor: 49.962

7.  Multiple binding sites of tricyclic antidepressant drugs to mammalian brain receptors.

Authors:  M Rehavi; M Sokolovsky
Journal:  Brain Res       Date:  1978-06-30       Impact factor: 3.252

8.  The in vivo binding of [3H]-desipramine and [3H]-chlorpromazine to areas in the rat brain.

Authors:  Z Yavin; A Biegon; M Segal; D Samuel
Journal:  Eur J Pharmacol       Date:  1978-09-15       Impact factor: 4.432

9.  Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression.

Authors:  A Randrup; C Braestrup
Journal:  Psychopharmacology (Berl)       Date:  1977-08-16       Impact factor: 4.530

10.  Studies on the subsynaptosomal distribution of psychotropic drugs in rat cerebral cortex.

Authors:  R Ishitani; T Iwamoto
Journal:  Jpn J Pharmacol       Date:  1977-12
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