Literature DB >> 488043

Cadmium, an effector in the synthesis of thionein.

S E Bryan, H A Hidalgo, V Koppa, H A Smith.   

Abstract

Cadmium can elicit the synthesis of thionein in liver cells independent of tissue-organ interactions. The metal diffuses across the plasma membrane and is partitioned between subcellular components in a time dependent manner such that thionein synthesis responds to levels of nonspecifically and specifically bound cytoplasmic metal. Cadmium appears to function at the transcriptional level, and the metal may act to increase the pool of specific m-RNA's.

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Year:  1979        PMID： 488043      PMCID： PMC1637499          DOI： 10.1289/ehp.7928281

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  20 in total

1.  Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex.

Authors:  J H KAGI; B L VALEE
Journal:  J Biol Chem       Date:  1960-12       Impact factor: 5.157

2.  Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

Authors:  J H Kägi; S R Himmelhoch; P D Whanger; J L Bethune; B L Vallee
Journal:  J Biol Chem       Date:  1974-06-10       Impact factor: 5.157

3.  Purification and some properties of Cd-binding protein from rat liver.

Authors:  D R Winge; K V Rajagopalan
Journal:  Arch Biochem Biophys       Date:  1972-12       Impact factor: 4.013

4.  Binding of mercury in the rat kidney by metallothionein.

Authors:  J M Wiśniewska; B Trojanowska; J Piotrowski; M Jakubowski
Journal:  Toxicol Appl Pharmacol       Date:  1970-05       Impact factor: 4.219

5.  Metallothionein synthesis as an indication of the parenchymal origin of cells cultured from liver.

Authors:  M R Daniel; M Webb; M Cempel
Journal:  Chem Biol Interact       Date:  1977-01       Impact factor: 5.192

6.  Cadmium and zinc binding in mammalian liver and kidneys.

Authors:  Z A Shaikh; O J Lucis
Journal:  Arch Environ Health       Date:  1972-06

7.  Cadmium-115 bound to nuclear and cytoplasmic proteins.

Authors:  H A Hidalgo; S E Bryan
Journal:  Toxicol Appl Pharmacol       Date:  1977-11       Impact factor: 4.219

8.  Hepatic copper-and zinc-binding proteins in ruminants. 1. Distribution of Cu and Zn among soluble proteins of livers of varying Cu and Zn content.

Authors:  I Bremner; R B Marshall
Journal:  Br J Nutr       Date:  1974-09       Impact factor: 3.718

9.  Induction of cadmium-thionein in isolated rat liver cells.

Authors:  H A Hidalgo; V Koppa; S E Bryan
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857

10.  Separation of two forms of rabbit metallothionein by isoelectric focusing.

Authors:  G F Nordberg; M Nordberg; M Piscator; O Vesterberg
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.857
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  3 in total

1.  Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA.

Authors:  D Y Wei; G K Andrews
Journal:  Nucleic Acids Res       Date:  1988-01-25       Impact factor: 16.971

2.  Uptake and binding of cadmium and mercury to metallothionein in rat hepatocyte primary cultures.

Authors:  R J Gerson; Z A Shaikh
Journal:  Biochem J       Date:  1982-11-15       Impact factor: 3.857

3.  The movement of zinc and copper from the fertilized egg into metallothionein-like proteins in developing chick hepatic tissue.

Authors:  B C Sandrock; S R Kern; S E Bryan
Journal:  Biol Trace Elem Res       Date:  1983-12       Impact factor: 3.738
  3 in total

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