Literature DB >> 486423

Diaspirins that cross-link beta chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate.

J A Walder, R H Zaugg, R Y Walder, J M Steele, I M Klotz.   

Abstract

Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, have been found to be potent acylating agents of intracellular hemoglobin (A or S) in vitro. Furthermore, each of these reagents cross-links beta chains of hemoglobin, probably at the beta cleft. The modified hemoglobins show increased oxygen affinities and reduced gelation or sickling tendencies.

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Year:  1979        PMID： 486423     DOI： 10.1021/bi00587a001

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  8 in total

1.  Identification of the sites of deoxyhaemoglobin PEGylation.

Authors:  Roberto Iafelice; Simone Cristoni; Dario Caccia; Rosaria Russo; Luigi Rossi-Bernardi; Kenneth C Lowe; Michele Perrella
Journal:  Biochem J       Date:  2007-04-01       Impact factor: 3.857

Review 2.  Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property.

Authors:  Piyusha P Pagare; Aref Rastegar; Osheiza Abdulmalik; Abdelsattar M Omar; Yan Zhang; Andrew Fleischman; Martin K Safo
Journal:  Expert Opin Ther Pat       Date:  2021-11-01       Impact factor: 6.714

Review 3.  Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin.

Authors:  Martin K Safo; Gregory J Kato
Journal:  Hematol Oncol Clin North Am       Date:  2014-01-21       Impact factor: 3.722

4.  Functional comparison of specifically cross-linked hemoglobins biased toward the R and T states.

Authors:  M B Johnson; J G Adamson; A G Mauk
Journal:  Biophys J       Date:  1998-12       Impact factor: 4.033

5.  HbXL99 alpha: a hemoglobin derivative that is cross-linked between the alpha subunits is useful as a blood substitute.

Authors:  S R Snyder; E V Welty; R Y Walder; L A Williams; J A Walder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

6.  Direct observation of photolysis-induced tertiary structural changes in hemoglobin.

Authors:  Shin-Ichi Adachi; Sam-Yong Park; Jeremy R H Tame; Yoshitsugu Shiro; Naoya Shibayama
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-28       Impact factor: 11.205

Review 7.  Modern cross-linking strategies for synthesizing acellular hemoglobin-based oxygen carriers.

Authors:  David Raphael Harris; Andre Francis Palmer
Journal:  Biotechnol Prog       Date:  2008 Nov-Dec

8.  Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions.

Authors:  Yiping Jia; Francine Wood; Paul W Buehler; Abdu I Alayash
Journal:  PLoS One       Date:  2013-03-29       Impact factor: 3.240
  8 in total

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