Literature DB >> 4856716

In vitro metabolism of T-2 toxin.

R A Ellison, F N Kotsonis.   

Abstract

Incubation of T-2 toxin with the 9,000 x g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver. HT-2 toxin was not produced when human plasma was the incubating medium nor was it produced by treatment of T-2 toxin with simulated gastric juice. T-2 toxin was stable in gastric juice for at least 1 h.

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Year:  1974        PMID： 4856716      PMCID： PMC380048          DOI： 10.1128/am.27.2.423-424.1974

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  3 in total

1.  Biological and chemical detection of trichothecene mycotoxins of Fusarium species.

Authors:  Y Ueno; N Sato; K Ishii; K Sakai; H Tsunoda
Journal:  Appl Microbiol       Date:  1973-04

2.  Chemical interconversion of T-2 and HT-2 toxins and related compounds.

Authors:  R Wei; F M Strong; E B Smalley; H K Schnoes
Journal:  Biochem Biophys Res Commun       Date:  1971-10-15       Impact factor: 3.575

3.  T-2 toxin as an emetic factor in moldy corn.

Authors:  R A Ellison; F N Kotsonis
Journal:  Appl Microbiol       Date:  1973-10
  3 in total
  19 in total

1.  Assay and relationship of HT-2 toxin and T-2 toxin formation in liquid culture.

Authors:  F N Kotsonis; R A Ellison
Journal:  Appl Microbiol       Date:  1975-07

2.  Microbial transformation of macrocyclic trichothecenes.

Authors:  G Pavanasasivam; B B Jarvis
Journal:  Appl Environ Microbiol       Date:  1983-08       Impact factor: 4.792

3.  Comparative studies on microbial and chemical modifications of trichothecene mycotoxins.

Authors:  T Yoshizawa; N Morooka
Journal:  Appl Microbiol       Date:  1975-07

4.  Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes.

Authors:  Jianshe Wang; Jun Jiang; Hongxia Zhang; Junping Wang; Hua Cai; Cheng Li; Kangbai Li; Jing Liu; Xuejiang Guo; Guangxun Zou; Dazhi Wang; Yiqun Deng; Jiayin Dai
Journal:  Mol Cell Proteomics       Date:  2011-06-16       Impact factor: 5.911

5.  Cross-reactivity of antibodies against T-2 with deepoxide T-2 toxin.

Authors:  R D Wei; S P Swanson; F S Chu
Journal:  Mycotoxin Res       Date:  1988-03       Impact factor: 3.833

6.  The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells.

Authors:  A Ramu; B Yagen; N Ramu
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

7.  Biotransformation and detoxification of T-2 toxin by soil and freshwater bacteria.

Authors:  S Beeton; A T Bull
Journal:  Appl Environ Microbiol       Date:  1989-01       Impact factor: 4.792

8.  Cytotoxicity and effects of T2-toxin on plasma proteins involved in coagulation, fibrinolysis and kallikrein-kinin system.

Authors:  H Johnsen; E Odden; B A Johnsen; A Bøyum; E Amundsen
Journal:  Arch Toxicol       Date:  1988-01       Impact factor: 5.153

9.  In vitro metabolism of T-2 toxin in rats.

Authors:  T Yoshizawa; S P Swanson; C J Mirocha
Journal:  Appl Environ Microbiol       Date:  1980-11       Impact factor: 4.792

10.  T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin.

Authors:  T Yoshizawa; S P Swanson; C J Mirocha
Journal:  Appl Environ Microbiol       Date:  1980-06       Impact factor: 4.792
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