Literature DB >> 16346370

Microbial transformation of macrocyclic trichothecenes.

G Pavanasasivam1, B B Jarvis.   

Abstract

A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3'-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.

Entities:  

Year:  1983        PMID： 16346370      PMCID： PMC239418          DOI： 10.1128/aem.46.2.480-483.1983

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  7 in total

1.  Enzymic inactivation of trichothecin and crotocin.

Authors:  I HORVATH; J M VARGA
Journal:  Nature       Date:  1961-10-07       Impact factor: 49.962

2.  In vitro metabolism of T-2 toxin.

Authors:  R A Ellison; F N Kotsonis
Journal:  Appl Microbiol       Date:  1974-02

3.  Isolation of potent new antileukemic trichothecenes from Baccharis megapotamica.

Authors:  S M Kupchan; D R Streelman; B B Jarvis; R G Dailey; A T Sneden
Journal:  J Org Chem       Date:  1977-12-23       Impact factor: 4.354

4.  Biological modification of trichothecene mycotoxins: acetylation and deacetylation of deoxynivalenols by Fusarium spp.

Authors:  T Yoshizawa; N Morooka
Journal:  Appl Microbiol       Date:  1975-01

5.  Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes.

Authors:  C A Claridge; H Schmitz
Journal:  Appl Environ Microbiol       Date:  1978-07       Impact factor: 4.792

6.  Antileukemic compounds derived from the chemical modification of macrocyclic trichothecenes. 1. Derivatives of verrucarin A.

Authors:  B B Jarvis; G P Stahly; G Pavanasasivam; E P Mazzola
Journal:  J Med Chem       Date:  1980-09       Impact factor: 7.446

7.  Interaction Between the Antibiotic Trichothecenes and the Higher Plant Baccharis megapotamica.

Authors:  B B Jarvis; J O Midiwo; D Tuthill; G A Bean
Journal:  Science       Date:  1981-10-23       Impact factor: 47.728
  7 in total
  1 in total

1.  New tricks for old dogs: Two new macrocyclic trichothecene epimers and absolute configuration of 16-hydroxyverrucarin B.

Authors:  Diana Kao; Laura Flores-Bocanegra; Huzefa A Raja; Blaise A Darveaux; Cedric J Pearce; Nicholas H Oberlies
Journal:  Phytochemistry       Date:  2020-01-10       Impact factor: 4.072
  1 in total

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