| Literature DB >> 485131 |
K K Lee, S L Karr, M M Wong, P D Hoeprich.
Abstract
The overall prognosis of primary amoebic meningoencephalitis remains poor. The results of this study support previous finding that amphotericin B is the most efficacious drug against the Naegleria species in in vitro testing. In addition, the methyl ester of amphotericin B, a new derivative, also appears to be an effective agent. Of the drug combinations studied, amphotericin B plus minocycline and amphotericin B plus tetracycline showed synergy. The clinical significance of these findings remains to be determined.Entities:
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Year: 1979 PMID: 485131 PMCID: PMC352825 DOI: 10.1128/AAC.16.2.217
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191