| Literature DB >> 484649 |
K von Maillot, H W Stuhlsatz, V Mohanaradhakrishnan, H Greiling.
Abstract
The glycosaminoglycans distribution pattern of uterine cervix samples obtained from 42 women of reproductive age was determined by means of proteolytic digestion and subsequent chromatographic separation. The following glycosaminoglycans were detected: chondroitin 4- and 6-sulfates, dermatan sulfate, hyaluronate, chondroitin, and keratan sulfate. The connective tissue of the uterine cervix shows a characteristic distribution pattern with regard to glycosaminoglycans which does not correspond to that found in any other tissue studied so far. Based on dry weight, the content of keratan sulfate increases during pregnancy while the concentration of chondroitin remains unchanged. The chondroitin sulfates and dermatan sulfate drop simultaneously. During labor chondroitin increases threefold. The hyaluronate content of the postpartum cervix is higher than that of the cervix in nonpregnant women. Both changes in the solubility of collagen as well as in the distribution pattern of the glycosaminoglycans seem to be related to cervical dilatation.Entities:
Keywords: Biology; Cervix--analysis; Clinical Research; Genitalia; Genitalia, Female; Histology; In Vitro; Laboratory Procedures; Physiology; Pregnancy; Reproduction; Research Methodology; Urogenital System; Uterus
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Year: 1979 PMID： 484649 DOI： 10.1016/0002-9378(79)90440-x
Source DB: PubMed Journal: Am J Obstet Gynecol ISSN： 0002-9378 Impact factor: 8.661