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Literature DB >> 1964036

Collagenase activity in the cervix of non-pregnant and pregnant women.

R Osmers¹, W Rath, B C Adelmann-Grill, C Fittkow, M Severényi, W Kuhn.

Abstract

Cervical biopsies were obtained from non pregnant patients and from pregnant at various stages of gestation and during labour. The tissues were extract with a Ca(++)-containing buffer, and collagenase activity was determined in these extracts using a solid phase assay in which triple helical 125I-labelled collagen was cleaved. Collagenase was detected in all samples but significantly elevated activity was only present in labour at 6-8 cm cervical dilatation. This provides direct evidence for the crucial role of specific collagen degradation during cervical ripening and dilatation.

Entities: Species

Mesh：

Substances：
Microbial Collagenase

Year: 1990 PMID： 1964036 DOI： 10.1007/bf02389578

Source DB: PubMed Journal: Arch Gynecol Obstet ISSN： 0932-0067 Impact factor: 2.344

32 in total

1. Enzymatic collagen degradation in the pregnant guinea pig cervix during physiological maturation of the cervix and after local application of prostaglandins.

Authors: W Rath; B C Adelmann-Grill; R Osmers; W Kuhn
Journal: Eur J Obstet Gynecol Reprod Biol Date: 1989-09 Impact factor: 2.435

2. Human skin fibroblast collagenase: interaction with substrate and inhibitor.

Authors: H G Welgus; J J Jeffrey; A Z Eisen; W T Roswit; G P Stricklin
Journal: Coll Relat Res Date: 1985-03

3. Latent and active forms of collagenase in rat uterine explant cultures: regulation of conversion by progestational steroids.

Authors: B Tyree; J Halme; J J Jeffrey
Journal: Arch Biochem Biophys Date: 1980-06 Impact factor: 4.013

4. Total, latent and active collagenase during the course of post-partum involution of the rat uterus. Effect of oestradiol.

Authors: J F Woessner
Journal: Biochem J Date: 1979-04-15 Impact factor: 3.857

5. Changes in the glycosaminoglycans distribution pattern in the human uterine cervix during pregnancy and labor.

Authors: K von Maillot; H W Stuhlsatz; V Mohanaradhakrishnan; H Greiling
Journal: Am J Obstet Gynecol Date: 1979-10-15 Impact factor: 8.661

6. Ripening of the human uterine cervix related to changes in collagen, glycosaminoglycans, and collagenolytic activity.

Authors: N Uldbjerg; G Ekman; A Malmström; K Olsson; U Ulmsten
Journal: Am J Obstet Gynecol Date: 1983-11-15 Impact factor: 8.661

7. [Correlation of human cervical ripening and glycoconjugates (glycosaminoglycans and glycoproteins) (author's transl)].

Authors: T Shimizu
Journal: Acta Obstet Gynaecol Jpn Date: 1980-12

8. Partial characterization of the macrophage factor that stimulates fibroblasts to produce collagenase and to degrade collagen.

Authors: G Huybrechts-Godin; C Peeters-Joris; G Vaes
Journal: Biochim Biophys Acta Date: 1985-07-30

2. Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche.

Authors: Karen V Lithgow; Vienna C H Buchholz; Emily Ku; Shaelen Konschuh; Ana D'Aubeterre; Laura K Sycuro
Journal: NPJ Biofilms Microbiomes Date: 2022-02-21 Impact factor: 7.290

2 in total