Literature DB >> 483186

Binding and ingestion of human lactoferrin by mouse alveolar macrophages.

B Markowetz, J L Van Snick, P L Masson.   

Abstract

59Fe-labelled human lactoferrin was found to be preferentially ingested by mouse alveolar macrophages (MAM) when compared to 59Fe-labelled human transferrin. The cells bound and ingested 125I-labelled iron-saturated and iron-free lactoferrin. The latter was digested faster (t1/2 = 5.8 hours), however, than the iron-saturated compound (t1/2 = 10.5 hours). The constant elimination of the Fe-lactoferrin complex by alveolar macrophages could enhance the bacteriostatic effect of lactoferrin in the pulmonary secretions.

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Year:  1979        PMID： 483186      PMCID： PMC471038          DOI： 10.1136/thx.34.2.209

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  7 in total

1.  [Comparative studies of the structure of human transferrin and lactotransferrin. "Fingerprinting" of the protease hydrolysates of both glycoproteins].

Authors:  G Spik; J Montreuil
Journal:  C R Seances Soc Biol Fil       Date:  1966

2.  Inhibition of bacteria by lactoferrin and other iron-chelating agents.

Authors:  J D Oram; B Reiter
Journal:  Biochim Biophys Acta       Date:  1968-12-23

3.  Immunohistochemical localization and bacteriostatic properties of an iron-binding protein from bronchial mucus.

Authors:  P L Masson; J F Heremans; J J Prignot; G Wauters
Journal:  Thorax       Date:  1966-11       Impact factor: 9.139

4.  Molecular weight, single-chain structure and amino acid composition of human lactoferrin.

Authors:  P Querinjean; P L Masson; J F Heremans
Journal:  Eur J Biochem       Date:  1971-06-11

5.  Iron-binding proteins in milk and resistance to Escherichia coli infection in infants.

Authors:  J J Bullen; H J Rogers; L Leigh
Journal:  Br Med J       Date:  1972-01-08

6.  The binding of human lactoferrin to mouse peritoneal cells.

Authors:  J L Van Snick; P L Masson
Journal:  J Exp Med       Date:  1976-12-01       Impact factor: 14.307

7.  The ingestion and digestion of human lactoferrin by mouse peritoneal macrophages and the transfer of its iron into ferritin.

Authors:  J L van Snick; B Markowetz; P L Masson
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307
  7 in total
  3 in total

1.  Clearance and binding of native and defucosylated lactoferrin.

Authors:  M J Imber; S V Pizzo
Journal:  Biochem J       Date:  1983-05-15       Impact factor: 3.857

2.  Lactoferrin in human prostate tissue.

Authors:  M van Sande; K Van Camp
Journal:  Urol Res       Date:  1981

3.  Human leukocyte elastase, cathepsin G, and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor.

Authors:  E J Campbell
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205
  3 in total

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