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Literature DB >> 4825614

Adrenal cortical degeneration and regeneration following administration of DDD.

J M Powers, G R Hennigar, G Grooms, J Nichols.

Abstract

Degeneration and regeneration of canine adrenal cortical cells following DDD administration are described. The degenerative phase is rapid in onset and dose related. It is morphologically characterized by profound cytoplasmic vacuolation due to severe mitochondrial damage, disruption of the smooth endoplasmic reticulum, autolysosomal response and lipid accumulation. Toxic necrosis with a mononuclear cell reaction and fibrosis also occurs. The regenerative phase consists of centripetal cellular regeneration, cellular repair and some residual damage. Several of the ultrastructural and biochemical findings are discussed in relation to the pertinent literature.

Entities: Chemical Disease Species

Mesh：

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Year: 1974 PMID： 4825614 PMCID： PMC1910812

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

10 in total

5. The effect of isomers of DDD on the ACTH-induced steroid output, histology and ultrastructure of the dog adrenal cortex.

Authors: M M Hart; R L Reagan; R H Adamson
Journal: Toxicol Appl Pharmacol Date: 1973-01 Impact factor: 4.219

6. Studies on the site of action of o,p'-DDD in the dog adrenal cortex. 1. Inhibition of ACTH-mediated pregnenolone synthesis.

Authors: M M Hart; J A Straw
Journal: Steroids Date: 1971-05 Impact factor: 2.668

7. Studies on the site of action of o,p'-DDD in the dog adrenal cortex. II. TPNH- and corticosteroid precursor-stimulation of o,p'-DDD inhibited steroidogenesis.

Authors: M M Hart; E S Swackhamer; J A Straw
Journal: Steroids Date: 1971-05 Impact factor: 2.668

3 in total

1. Adrenocorticolytic DDT-metabolites: studies in mink, Mustela vison and otter, Lutra lutra.

Authors: C J Jönsson; B O Lund; I Brandt
Journal: Ecotoxicology Date: 1993-03 Impact factor: 2.823

2. Hyperadrenocorticism in dogs: a study of eight cases.

Authors: J G Spearman; P B Little
Journal: Can Vet J Date: 1978-02 Impact factor: 1.008

3. Adreno-leukodystrophy (sex-linked Schilder's disease). A pathogenetic hypothesis based on ultrastructural lesions in adrenal cortex, peripheral nerve and testis.

Authors: J M Powers; H H Schaumburg
Journal: Am J Pathol Date: 1974-09 Impact factor: 4.307

3 in total

Adrenal cortical degeneration and regeneration following administration of DDD.

1. SPECIFICITY OF ENZYME INHIBITION BY DDD.

2. Action of 1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane on dog adrenal cortex.

3. Effects of o,p' DDD on histology and 17-hydroxycorticosteroid output of the dog adrenal cortex.

4. Ultrastructure of adrenal cortex of the dog during treatment with DDD.

5. The effect of isomers of DDD on the ACTH-induced steroid output, histology and ultrastructure of the dog adrenal cortex.

6. Studies on the site of action of o,p'-DDD in the dog adrenal cortex. 1. Inhibition of ACTH-mediated pregnenolone synthesis.

7. Studies on the site of action of o,p'-DDD in the dog adrenal cortex. II. TPNH- and corticosteroid precursor-stimulation of o,p'-DDD inhibited steroidogenesis.

8. The effect of o,p'DDD on cortisol and hexobarbital metabolism.

9. The ultrastructure of the normal dog adrenal.

10. Studies on DDD, 2,2-bis (parachlorophenyl)-1,1-dichloroethane.

1. Adrenocorticolytic DDT-metabolites: studies in mink, Mustela vison and otter, Lutra lutra.

2. Hyperadrenocorticism in dogs: a study of eight cases.

3. Adreno-leukodystrophy (sex-linked Schilder's disease). A pathogenetic hypothesis based on ultrastructural lesions in adrenal cortex, peripheral nerve and testis.