Action of 1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane on dog adrenal cortex.

A single intravenous injection of op'DDD (1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation by adrenocorticotrophic hormone and an inhibition of glucose-6-phosphate dehydrogenase activity. The inhibition of glucose-6-phosphate dehydrogenase activity might explain the effect of op'DDD on corticosteroid production.