Literature DB >> 4825241

Cytotoxic activity of mouse macrophages studied by various inhibitors.

H Melsom.   

Abstract

The influence of various inhibitors on the cytolytic potential of mouse macrophages against syngeneic erythrocytes has been investigated in vitro by isotope techniques. Intact macrophage membrane and cell metabolism was essential for full cytotoxic activity. The process was completely blocked by anaerobiosis and cold. ATP from both mitochondrial respiration and glycolysis seems to be the high energy intermediate which is utilized during the cytotoxic activity of macrophages leading to target cell lysis. The process did not depend on concomitant DNA transcription, translation, or protein synthesis.

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Year:  1974        PMID： 4825241      PMCID： PMC2139660          DOI： 10.1084/jem.139.5.1049

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  13 in total

1.  Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complement.

Authors:  I Goldstein; S Hoffstein; J Gallin; G Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

2.  Inhibition of cell fusion by local anaesthetics and tranquillizers.

Authors:  G Poste; P Reeve
Journal:  Exp Cell Res       Date:  1972-06       Impact factor: 3.905

3.  Effects of chlorpromazine and propranolol on in vitro thyroid activation by thyrotropin, long-acting thyroid stimulator and dibutyryl cyclic-AMP.

Authors:  T Onaya; D H Solomon
Journal:  Endocrinology       Date:  1969-12       Impact factor: 4.736

4.  Lytic effect of mouse macrophages on red cells.

Authors:  R Seljelid; H Melsom; A Munthekaas
Journal:  Exp Cell Res       Date:  1972-12       Impact factor: 3.905

Review 5.  Membrane stabilization by drugs: tranquilizers, steroids, and anesthetics.

Authors:  P M Seeman
Journal:  Int Rev Neurobiol       Date:  1966       Impact factor: 3.230

6.  The effect of gold salt on lysosomal enzymes of the peritoneal macrophage.

Authors:  R H Persellin; M Ziff
Journal:  Arthritis Rheum       Date:  1966-02

7.  Inhibition of cellular transport processes by 5-thio-D-glucopyranose.

Authors:  R L Whistler; W C Lake
Journal:  Biochem J       Date:  1972-12       Impact factor: 3.857

8.  Cytotoxicity of immune guinea-pig cells. II. The mechanism of macrophage cytotoxicity.

Authors:  A Temple; G Loewi; P Davies; A Howard
Journal:  Immunology       Date:  1973-04       Impact factor: 7.397

9.  The cytotoxic effect of mouse macrophages on syngeneic and allogeneic erythrocytes.

Authors:  H Melsom; R Seljelid
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307

10.  The regulation of pinocytosis in mouse macrophages. I. Metabolic requirements as defined by the use of inhibitors.

Authors:  Z A Cohn
Journal:  J Exp Med       Date:  1966-10-01       Impact factor: 14.307
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  2 in total

1.  Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

Authors:  C F Nathan; S C Silverstein; L H Brukner; Z A Cohn
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307

2.  Evidence for a cytolytic factor released by macrophages.

Authors:  H Melsom; G Kearny; S Gruca; R Seljelid
Journal:  J Exp Med       Date:  1974-10-01       Impact factor: 14.307
  2 in total

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