Literature DB >> 4824991

The effect of serum protein concentrations on the specificity of the radioimmunoassay of carcinoembryonic antigen in malignant neoplasia and non-neoplastic disease.

J M Crawley, B E Northam, J P King, J C Leonard, S N Booth, P W Dykes.   

Abstract

Carcinoembryonic antigen (CEA) has been measured in parallel with seven serum proteins and seromucoids in the sera of patients with malignant neoplasia and non-neoplastic disease. In the total group significant correlations were found between CEA and seromucoids and between CEA and several serum proteins. However, with two exceptions, when the individual disease groups were examined no correlation was seen. It is concluded that abnormal concentrations of the specific proteins measured do not consistently interfere in the CEA radioimmunoassay and do not explain the high CEA levels in patients with non-neoplastic diseases.

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Year:  1974        PMID： 4824991      PMCID： PMC478025          DOI： 10.1136/jcp.27.2.130

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  The clinical significance of seromucoids in regional ileitis and ulcerative colitis.

Authors:  W T COOKE; D I FOWLER; E V COX; R GADDIE; M J MEYNELL
Journal:  Gastroenterology       Date:  1958-05       Impact factor: 22.682

2.  Seromucoid in hepatobiliary disease.

Authors:  E E MANDEL; T L GORSUCH; G E COOPER
Journal:  Clin Chem       Date:  1955-08       Impact factor: 8.327

Review 3.  Plasma proteins. A review.

Authors:  P Simmons; R Penny; I Goller
Journal:  Med J Aust       Date:  1969-09-06       Impact factor: 7.738

4.  Radioimmune assay of carcinoembryonic antigen.

Authors:  M L Egan; J T Lautenschleger; J E Coligan; C W Todd
Journal:  Immunochemistry       Date:  1972-03

5.  Demonstration of an antigen common to several varieties of neoplasia.

Authors:  P Lo Gerfo; J Krupey; H J Hansen
Journal:  N Engl J Med       Date:  1971-07-15       Impact factor: 91.245

6.  Collaborative study of estimates by radioimmunoassay of insulin concentrations in plasma samples examined in groups of five or six laboratories.

Authors:  P M Cotes; M V Mussett; I Berryman; R Ekins; S Glover; N Hales; W M Hunter; C Lowy; R W Neville; E Samols; P M Woodward
Journal:  J Endocrinol       Date:  1969-12       Impact factor: 4.286

7.  Qualitative and quantitative alterations in serum serumucoid in malignant neoplastic disease.

Authors:  H Bacchus; E R Kennedy; J Balckwell
Journal:  Cancer       Date:  1967-10       Impact factor: 6.860

8.  Serum carcinoembryonic antigen in clinical disorders.

Authors:  S N Booth; J P King; J C Leonard; P W Dykes
Journal:  Gut       Date:  1973-10       Impact factor: 23.059

9.  The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.

Authors:  D M Thomson; J Krupey; S O Freedman; P Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1969-09       Impact factor: 11.205

10.  Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.

Authors:  D J Laurence; U Stevens; R Bettelheim; D Darcy; C Leese; C Turberville; P Alexander; E W Johns; A M Neville
Journal:  Br Med J       Date:  1972-09-09
  10 in total
  1 in total

1.  [Carcinofetal antigens. III. Further carcinofetal antigens (author's transl)].

Authors:  R Lamerz; A Fateh-Moghadam
Journal:  Klin Wochenschr       Date:  1975-05-01
  1 in total

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