Literature DB >> 4817187

Interaction between doxycycline and barbiturates.

P J Neuvonen, O Penttilä.   

Abstract

In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug metabolism should be used cautiously in combination with doxycycline, since this might result in therapeutically inadequate serum concentrations of the antibiotic.

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Year:  1974        PMID： 4817187      PMCID： PMC1633645          DOI： 10.1136/bmj.1.5907.535

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  5 in total

Review 1.  Clinically important drug interactions.

Authors:  L F Prescott
Journal:  Drugs       Date:  1973       Impact factor: 9.546

2.  Dose-dependent enzyme induction.

Authors:  A Breckenridge; M L Orme; L Davies; S S Thorgeirsson; D S Davies
Journal:  Clin Pharmacol Ther       Date:  1973 Jul-Aug       Impact factor: 6.875

3.  Simplified, accurate method for antibiotic assay of clinical specimens.

Authors:  J V Bennett; J L Brodie; E J Benner; W M Kirby
Journal:  Appl Microbiol       Date:  1966-03

4.  Clinical implications of enzyme induction.

Authors:  A Breckenridge; M Orme
Journal:  Ann N Y Acad Sci       Date:  1971-07-06       Impact factor: 5.691

5.  Interference of iron with the absorption of tetracyclines in man.

Authors:  P J Neuvonen; G Gothoni; R Hackman; K Björksten
Journal:  Br Med J       Date:  1970-11-28
  5 in total
  16 in total

1.  Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.

Authors:  Paul N Newton; Jean-François Chaulet; Alan Brockman; Wirongrong Chierakul; Arjen Dondorp; Ronatrai Ruangveerayuth; Sornchai Looareesuwan; Cyril Mounier; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

2.  Steady-state plasma nortriptyline concentrations in epileptic patients.

Authors:  R A Braithwaite; R J Flanagan; A Richens
Journal:  Br J Clin Pharmacol       Date:  1975-10       Impact factor: 4.335

3.  Effect of enzyme induction on bioavailability of hetacillin in patients treated with anticonvulsants and chlorpromazine.

Authors:  P Galanopoulou; C Karageorgiou; K Dimakopoulou
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Jan-Mar       Impact factor: 2.441

4.  Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid.

Authors:  K M Deppermann; H Lode; G Höffken; G Tschink; C Kalz; P Koeppe
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

5.  Interactions with the absorption of tetracyclines.

Authors:  P J Neuvonen
Journal:  Drugs       Date:  1976       Impact factor: 9.546

6.  Interaction between doxycycline and some antiepileptic drugs.

Authors:  O Penttilå; P J Neuvonen; K Aho; R Lehtovaara
Journal:  Br Med J       Date:  1974-06-01

Review 7.  Clinical implications of enzyme induction and enzyme inhibition.

Authors:  B K Park; A M Breckenridge
Journal:  Clin Pharmacokinet       Date:  1981 Jan-Feb       Impact factor: 6.447

Review 8.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 9.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

10.  Comparative study of the effects of some inducers with or without protein binding properties on bioavailability of isoxazolylpenicillins in rats.

Authors:  M Couvaris; P Galanopoulou; C Karageorgiou; S Theodosopoulos; D Varonos
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Jul-Sep       Impact factor: 2.441
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