Literature DB >> 26677

Studies on the formation of gamma-aminobutyric acid from putrescine in rat organs and purification of its synthetic enzyme from rat intestine.

M Tsuji, T Nakajima.   

Abstract

The formation of gamma-aminobutyric acid (GABA) from putrescine was examined in organs of rats using radioactive putrescine. Radioactive GABA was detected in all the organs of a rat injected intraperitoneally with radioactive putrescine, and the highest radioactivity of GABA was observed in the small intestine. The enzyme involved in this formation was purified from small intestine and identified as a diamine oxidase, histaminase, from the properties of the enzyme. Activity of the enzyme was found in all the organs of rat, and the highest activity was observed in the small intestine.

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Year:  1978        PMID: 26677     DOI: 10.1093/oxfordjournals.jbchem.a132050

Source DB:  PubMed          Journal:  J Biochem        ISSN: 0021-924X            Impact factor:   3.387


  8 in total

1.  Absence of diamine oxidase activity from rabbit and rat lungs.

Authors:  S B Rao; K S Rao; H M Mehendale
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857

2.  Involvement of diamine oxidase in catabolism of 14C-putrescine in mice in vivo with special reference to the formation of gamma-aminobutyric acid.

Authors:  W A Fogel; T Bieganski; R W Schayer; C Maslinski
Journal:  Agents Actions       Date:  1981-12

3.  Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.

Authors:  N Seiler; G Bink; J Grove
Journal:  Neurochem Res       Date:  1979-08       Impact factor: 3.996

4.  Histaminase activity in rat lung and its comparison with intestinal mucosal diamine oxidase.

Authors:  G Ignesti; G Banchelli; L Raimondi; R Pirisino; F Buffoni
Journal:  Agents Actions       Date:  1992-03

5.  On the turnover of polyamines spermidine and spermine in mouse brain and other organs.

Authors:  H Antrup; N Seiler
Journal:  Neurochem Res       Date:  1980-02       Impact factor: 3.996

Review 6.  Putrescine metabolism and the study of diamine oxidase activity in vivo.

Authors:  T L Sourkes; K Missala
Journal:  Agents Actions       Date:  1981-04

7.  Diamine oxidase in the hen.

Authors:  T Biegański; M A Ulatowska
Journal:  Agents Actions       Date:  1983-04

8.  B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity.

Authors:  Alexis Vogelzang; Michio Miyajima; Yuki Sugiura; Baihao Zhang; Yibo Wu; Kenji Chamoto; Rei Nakano; Ryusuke Hatae; Rosemary J Menzies; Kazuhiro Sonomura; Nozomi Hojo; Taisaku Ogawa; Wakana Kobayashi; Yumi Tsutsui; Sachiko Yamamoto; Mikako Maruya; Seiko Narushima; Keiichiro Suzuki; Hiroshi Sugiya; Kosaku Murakami; Motomu Hashimoto; Hideki Ueno; Takashi Kobayashi; Katsuhiro Ito; Tomoko Hirano; Katsuyuki Shiroguchi; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan
Journal:  Nature       Date:  2021-11-03       Impact factor: 69.504

  8 in total

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