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Literature DB >> 481615

Effect of age on levels of diazepam in plasma and brain of rats.

Abstract

The pharmacokinetics and distribution in brain and cerebellum of diazepam after a single dose were studied in middle aged (6 months) and old (18 months) rats. Following the single intravenous bolus of 5 mg/kg diazepam was eliminated more slowly in old rats (T 1/2 (beta) = 3.1 H) than in middle aged rats (1.4H). This was due to an increase in the apparent volume of distribution Vd beta from 11.0 l/kg (control rats) to 29.5 l/kg. Concentrations of diazepam in brain and cerebellum were in the same range (0.5-1.1 ng/mg) in both groups after this dose. We conclude that the distribution of diazepam is age-dependent which might be due to an altered body composition.

Entities: Chemical Gene Species

Mesh：

Substances：
Diazepam

Year: 1979 PMID： 481615 DOI： 10.1007/bf00498459

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

11 in total

Review 1. PHARMACOLOGIC ASPECTS OF AGING: A SURVEY OF THE EFFECT OF INCREASING AGE ON DRUG ACTIVITY IN ADULTS.

Authors: A D BENDER
Journal: J Am Geriatr Soc Date: 1964-02 Impact factor: 5.562

Review 2. New concepts on the mechanism of action of benzodiazepines.

Authors: E Costa; A Guidotti; C C Mao; A Suria
Journal: Life Sci Date: 1975-07-15 Impact factor: 5.037

3. Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.

Authors: C C Mao; A Guidotti; E Costa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

4. Benzodiazepine receptors in rat brain.

Authors: R F Squires; C Brastrup
Journal: Nature Date: 1977-04-21 Impact factor: 49.962

5. Benzodiazepine receptor: demonstration in the central nervous system.

Authors: H Möhler; T Okada
Journal: Science Date: 1977-11-25 Impact factor: 47.728

6. Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age.

Authors:
Journal: N Engl J Med Date: 1973-02-08 Impact factor: 91.245

4. Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.

Authors: S J Dolin; T L Patch; M Rabbani; R J Siarey; A R Bowhay; H J Little
Journal: Br J Pharmacol Date: 1990-11 Impact factor: 8.739

4 in total

Effect of age on levels of diazepam in plasma and brain of rats.

Review 1. PHARMACOLOGIC ASPECTS OF AGING: A SURVEY OF THE EFFECT OF INCREASING AGE ON DRUG ACTIVITY IN ADULTS.

Review 2. New concepts on the mechanism of action of benzodiazepines.

3. Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam.

4. Benzodiazepine receptors in rat brain.

5. Benzodiazepine receptor: demonstration in the central nervous system.

6. Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age.

7. Effects of change in elimination on varous parameters of the two-compartment open model.

8. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment.

9. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

10. Theophylline disposition in obesity.

Review 1. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

2. The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma.

3. The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.

4. Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.