Literature DB >> 481459

The effect of a tumor promotor, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), on sister-chromatid exchange formation in cultured Chinese hamster cells.

K S Loveday, S A Latt.   

Abstract

The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) does not increase the sister-chromatid exchange (SCE) frequency in either Chinese hamster ovary (CHO) or lung (V 79) cells which are cultured in the presence of 5-bromodeoxyuridine. Moreover, TPA does not alter the induction of SCEs in CHO cells by mitomycin C during the first 3 cycles following addition of the alkylating agent. These SCE induction data do not by themselves support the hypothesis that tumor promotion by TPA depends on the enhancement of mitotic recombination.

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Year:  1979        PMID： 481459     DOI： 10.1016/0165-1218(79)90030-2

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  11 in total

Review 1.  Sister chromatid exchange analysis.

Authors:  S A Latt; R R Schreck
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

2.  On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

Authors:  A Varshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

3.  Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.

Authors:  R Seif
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103

4.  A DNA-recombinogenic activity in human cells.

Authors:  K Kenne; S Ljungquist
Journal:  Nucleic Acids Res       Date:  1984-04-11       Impact factor: 16.971

5.  Enhancement of carcinogen-induced mutations or recombinations by 12-O-tetradecanoyl-phorbol-13-acetate in the mammalian spot test.

Authors:  R Fahrig
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

6.  Chemical induction of interleukin-8, a proinflammatory chemokine, in human epidermal keratinocyte cultures and its relation to cytogenetic toxicity.

Authors:  J L Wilmer; M I Luster
Journal:  Cell Biol Toxicol       Date:  1995-02       Impact factor: 6.691

7.  Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations.

Authors:  J A DiPaolo; S C Amsbaugh; N C Popescu
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

8.  Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine transformation of Syrian hamster cells by a phorbol diester is independent of sister chromatid exchanges and chromosome aberrations.

Authors:  N C Popescu; S C Amsbaugh; J A DiPaolo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Bloom syndrome B-lymphoblastoid cells are hypersensitive towards carcinogen and tumor promoter-induced chromosomal alterations and growth in agar.

Authors:  Y Shiraishi
Journal:  EMBO J       Date:  1985-10       Impact factor: 11.598

Review 10.  Chromosome aberrations and their relevance to metal carcinogenesis.

Authors:  H Vainio; M Sorsa
Journal:  Environ Health Perspect       Date:  1981-08       Impact factor: 9.031
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