Literature DB >> 481430

Vitamin C is positive in the DNA synthesis inhibition and sister-chromatid exchange tests.

S M Galloway, R B Painter.   

Abstract

Ascorbate caused a dose-dependent increase in sister-chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells and in human lymphocytes. Moreover, in the DNA synthesis inhibition test with HeLa cells, ascorbate gave results typical of DNA-damaging chemicals. Catalase reduced SCE induction by ascorbate, prevented its cytotoxicity in CHO cells, and prevented its effect on HeLa DNA synthesis. Ascorbate reduced induction of SCE in CHO cells by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by direct inactivation of MNNG.

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Year:  1979        PMID： 481430     DOI： 10.1016/0027-5107(79)90022-8

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  4 in total

Review 1.  Sister chromatid exchange analysis.

Authors:  S A Latt; R R Schreck
Journal:  Am J Hum Genet       Date:  1980-05       Impact factor: 11.025

2.  Lack of effect of vitamin C on the incidence of chromosome anomalies induced by influenza virus in germ cells of mice.

Authors:  K Pichan; H Polasa
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

3.  Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

Authors:  J Błasiak; A Trzeciak; A Gasiorowska; J Drzewoski; E Małecka-Panas
Journal:  Plant Foods Hum Nutr       Date:  2002       Impact factor: 3.921

4.  The genotoxicity of vitamin C in vitro.

Authors:  Hilada Nefić
Journal:  Bosn J Basic Med Sci       Date:  2008-05       Impact factor: 3.363
  4 in total

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