Literature DB >> 4790585

DD-carboxypeptidase-transpeptidase and killing site of beta-lactam antibiotics in Streptomyces strains R39, R61, and K11.

J Dusart, A Marquet, J M Ghuysen, J M Frère, R Moreno, M Leyh-Bouille, K Johnson, C Lucchi, H R Perkins, M Nieto.   

Abstract

Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd-carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of beta-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, beta-lactamase activity was not involved in susceptibility to beta-lactam antibiotics.

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Year:  1973        PMID： 4790585      PMCID： PMC444384          DOI： 10.1128/AAC.3.2.181

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  [Bacteriolytic activities of actinomycetin from Streptomyces albus G].

Authors:  J M GHUYSEN
Journal:  Arch Int Physiol Biochim       Date:  1957-04

2.  Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis.

Authors:  P M Blumberg; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

3.  Isolation, partial characterization of the cytoplasmic membrane fraction of Streptomyces albus G and DD-carboxypeptidase localization.

Authors:  E Muñoz; A Marquet; V Larraga; J Coyette
Journal:  Arch Mikrobiol       Date:  1972

4.  Penicillin-sensitive DD-carboxypeptidases from Streptomyces strains R39 and K11.

Authors:  M Leyh-Bouille; M Nakel; J M Frère; K Johnson; J M Ghuysen; M Nieto; H R Perkins
Journal:  Biochemistry       Date:  1972-03-28       Impact factor: 3.162

5.  Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.

Authors:  E M Wise; J T Park
Journal:  Proc Natl Acad Sci U S A       Date:  1965-07       Impact factor: 11.205

6.  An introspective view of penicillinase.

Authors:  A K Saz
Journal:  J Cell Physiol       Date:  1970-12       Impact factor: 6.384

7.  Penicillin-sensitive DD-carboxypeptidase from Streptomyces strain R 61.

Authors:  M Leyh-Bouille; J Coyette; J M Ghuysen; J Idczak; H R Perkins; M Nieto
Journal:  Biochemistry       Date:  1971-05-25       Impact factor: 3.162

8.  Exocellular beta-lactamases of Streptomyces albus G and strains R39 and K11.

Authors:  K Johnson; J Dusart; J N Campbell; J M Ghuysen
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191

9.  Transpeptidase activity of Streptomyces D-alanyl-D carboxypeptidases.

Authors:  J J Pollock; J M Ghuysen; R Linder; M R Salton; H R Perkins; M Nieto; M Leyh-Bouille; J M Frere; K Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

10.  The inhibition of mucopeptide synthesis by benzylpenicillin in relation to irreversible fixation of the antibiotic by staphylococci.

Authors:  H J Rogers
Journal:  Biochem J       Date:  1967-04       Impact factor: 3.857
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  11 in total

1.  Specificity inversion of Ochrobactrum anthropi D-aminopeptidase to a D,D-carboxypeptidase with new penicillin binding activity by directed mutagenesis.

Authors:  Michaël Delmarcelle; Marie-Caroline Boursoit; Patrice Filée; Stéphane Lucius Baurin; Jean-Marie Frère; Bernard Joris
Journal:  Protein Sci       Date:  2005-09       Impact factor: 6.725

2.  Mode of interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39.

Authors:  N Fuad; J M Frère; J M Ghuysen; C Duez; M Iwatsubo
Journal:  Biochem J       Date:  1976-06-01       Impact factor: 3.857

Review 3.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

4.  Molecular weight and amino acid composition of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.

Authors:  J M Frère; J M Ghuysen; H R Perkins; M Nieto
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857

5.  [Metabolic products of microorganisms. 134. Stenothricin, a new inhibitor of the bacterial cell wall synthesis (author's transl)].

Authors:  A Hasenböhler; H Kneifel; W A König; H Zähner; H J Zeiler
Journal:  Arch Microbiol       Date:  1974       Impact factor: 2.552

6.  Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales.

Authors:  Jean-Emmanuel Hugonnet; Nabila Haddache; Carole Veckerlé; Lionel Dubost; Arul Marie; Noriyasu Shikura; Jean-Luc Mainardi; Louis B Rice; Michel Arthur
Journal:  Antimicrob Agents Chemother       Date:  2014-01-06       Impact factor: 5.191

7.  Peptidoglycan transpeptidase inhibition in Pseudomonas aeruginosa and Escherichia coli by Penicillins and Cephalosporins.

Authors:  B A Moore; S Jevons; K W Brammer
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

8.  Exocellular beta-lactamases of Streptomyces albus G and strains R39 and K11.

Authors:  K Johnson; J Dusart; J N Campbell; J M Ghuysen
Journal:  Antimicrob Agents Chemother       Date:  1973-02       Impact factor: 5.191

9.  Role of phosphatases in the biosynthesis of chlortetracycline in Streptomyces aureofaciens.

Authors:  V Jechová; E Curdová; Z Hostálek
Journal:  Folia Microbiol (Praha)       Date:  1982       Impact factor: 2.099

10.  Kinetics of concomitant transfer and hydrolysis reactions catalysed by the exocellular DD-carboxypeptidase-transpeptidase of streptomyces R61.

Authors:  J M Frère; J M Ghuysen; H R Perkins; M Nieto
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857
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