Literature DB >> 477886

Alteration of plasma ketamine levels in mice by probenecid.

J N Davisson.   

Abstract

Probenecid increases plasma ketamine levels in mice concurrently with an enhancement of duration of loss of righting reflex. The magnitude of these changes is directly related to the dose of ketamine and intervals between administration of compounds. Plasma levels of anesthetic are similar for all animals upon termination of hypnosis.

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Year:  1979        PMID： 477886     DOI： 10.1007/bf01949953

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  The development of an acute tolerance to ketamine.

Authors:  J F Cumming
Journal:  Anesth Analg       Date:  1976 Nov-Dec       Impact factor: 5.108

2.  Interaction between sedative premedicants and ketamine in man in isolated perfused rat livers.

Authors:  J N Lo; J F Cumming
Journal:  Anesthesiology       Date:  1975-09       Impact factor: 7.892

3.  KINETICS OF DRUG METABOLISM BY HEPATIC MICROSOMES.

Authors:  A RUBIN; T R TEPHLY; G J MANNERING
Journal:  Biochem Pharmacol       Date:  1964-07       Impact factor: 5.858

4.  On the mechanism of action of probenecid on renal tubular secretion.

Authors:  I M WEINER; J A WASHINGTON; G H MUDGE
Journal:  Bull Johns Hopkins Hosp       Date:  1960-06

5.  Metabolites of probenecid. Chemical, physical, and pharmacological studies.

Authors:  Z H Israili; J M Percel; R F Cunningham; P G Dayton; T F Yü; A B Gutman; K R Long; R C Long; J H Goldstein
Journal:  J Med Chem       Date:  1972-07       Impact factor: 7.446

6.  Biliary excretion of probenecid and its glucuronide.

Authors:  A M Guarino; L S Schanker
Journal:  J Pharmacol Exp Ther       Date:  1968-12       Impact factor: 4.030

Review 7.  Enhancement and inhibition of drug metabolism.

Authors:  M W Anders
Journal:  Annu Rev Pharmacol       Date:  1971       Impact factor: 13.820

8.  Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.

Authors:  N H Neef; T N Tozer; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1967-11       Impact factor: 4.030

9.  Active transport of chlorothiazide into bile.

Authors:  L G Hart; L S Schanker
Journal:  Am J Physiol       Date:  1966-09

10.  Effect of ketamine anaesthesia on the content of monoamines and their metabolites in the rat brain.

Authors:  P Ylitalo; L Saarnivaara; L Ahtee
Journal:  Acta Anaesthesiol Scand       Date:  1976       Impact factor: 2.105
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