| Literature DB >> 1033693 |
Abstract
A rapidly developing tolerance to the hypnotic effect of ketamine in rats and mice has been investigated. On the basis of plasma and brain concentrations of ketamine at the time the animals wakened, it seemed likely that a central nervous system tolerance to the drug explained the shortened sleeping times noted.Entities:
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Year: 1976 PMID: 1033693 DOI: 10.1213/00000539-197611000-00008
Source DB: PubMed Journal: Anesth Analg ISSN: 0003-2999 Impact factor: 5.108