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Literature DB >> 14169717

CYTOLOGICAL EVIDENCE FOR CROSSING-OVER IN VITRO IN HUMAN LYMPHOID CELLS.

Abstract

In human blood cells dividing in vitro two chromosomes are occasionally found intimately associated in a quadriradial configuration (Qr). A Qr by traditional interpretation is the result of chromatid interchange. Since the configurations in blood cells often are equal and symmetrical and are composed of homologous chromosomes, they are considered cytological evidence that somatic crossing-over may occur in mammalian cells.

Entities: Species

Keywords: CELL DIVISION; CHROMOSOMES; EXPERIMENTAL LAB STUDY; GENETICS, HUMAN; LEUKOCYTES; TISSUE CULTURE

Mesh：

Year: 1964 PMID： 14169717 DOI： 10.1126/science.144.3616.298

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

61 in total

1. Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.

Authors: D E Comings
Journal: Humangenetik Date: 1975-07-23

9. Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26.

Authors: M Charron; R Hancock
Journal: Chromosoma Date: 1991-02 Impact factor: 4.316

10. [Non-random position of homologous chromosomes (no. 9 and YY) in interphase nuclei of human fibroblasts (author's transl)].

Authors: M Spaeter
Journal: Humangenetik Date: 1975

CYTOLOGICAL EVIDENCE FOR CROSSING-OVER IN VITRO IN HUMAN LYMPHOID CELLS.

1. Implications of somatic recombination and sister chromatid exchange in Bloom's syndrome and cells treated with mitomycin C.

2. Interphase chromosome arrangement in Anopheles atroparvus.

3. Constitutional hyperrecombinability and its consequences.

4. Somatic recombination of duplicated genes: an hypothesis on the origin of antibody diversity.

5. Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.

6. Distribution of human chromosomes on the metaphase plate using banding techniques.

7. Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes.

8. Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder.

9. Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26.

10. [Non-random position of homologous chromosomes (no. 9 and YY) in interphase nuclei of human fibroblasts (author's transl)].