Literature DB >> 4762760

The metabolism of acetamidothiazoles in the rat. 2-acetamido-4-chloromethylthiazole.

D H Chatfield, W H Hunter.   

Abstract

2-Acetamido-4-chloromethylthiazole is metabolized in the rat to (2-acetamido-4-thiazolylmethyl)mercapturic acid and 2-acetamidothiazole-4-carboxylic acid. 2-Acetamido-4-methylthiomethylthiazole and the corresponding sulphoxide and sulphone are also produced as minor metabolites. The identification of the metabolites is described and their formation investigated. Quantitative results on the excretion of the metabolites labelled with (14)C are reported.

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Year:  1973        PMID： 4762760      PMCID： PMC1177895          DOI： 10.1042/bj1340879

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  A sensitive qualitative test for sulphoxides on paper chromatograms.

Authors:  J F THOMPSON; W N ARNOLD; C J MORRIS
Journal:  Nature       Date:  1963-01-26       Impact factor: 49.962

2.  Metabolism of some omega-halogenoalkylbenzenes and related alcohols in the rabbit.

Authors:  H G BRAY; S P JAMES; W V THORPE
Journal:  Biochem J       Date:  1958-12       Impact factor: 3.857

3.  The formation of mercapturic acids. 2. The possible role of glutathionase.

Authors:  H G BRAY; T J FRANKLIN; S P JAMES
Journal:  Biochem J       Date:  1959-04       Impact factor: 3.857

4.  Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

Authors:  R H KNIGHT; L YOUNG
Journal:  Biochem J       Date:  1958-09       Impact factor: 3.857

5.  The metabolism of acetamidothiazoles in the rat. 2-Acetamido-, 2-acetamido-4-methyl- and 2-acetamido-4-phenyl-thiazole.

Authors:  D H Chatfield; W H Hunter
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857
  5 in total
  3 in total

1.  Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849) in rats.

Authors:  M Yabuki; J Shimakura; M Ito; H Kanamaru; K Iba; I Nakatsuka
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Jan-Mar       Impact factor: 2.441

Review 2.  Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.

Authors:  Arthur J L Cooper; Boris F Krasnikov; Zoya V Niatsetskaya; John T Pinto; Patrick S Callery; Maria T Villar; Antonio Artigues; Sam A Bruschi
Journal:  Amino Acids       Date:  2010-03-22       Impact factor: 3.520

3.  Studies on the toxicology of hexachlorobenzene. IV. Sulphur-containing metabolites.

Authors:  G Koss; W Koransky; K Steinbach
Journal:  Arch Toxicol       Date:  1979-04-23       Impact factor: 5.153
  3 in total

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