Literature DB >> 4759939

The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.

T J Powles, S A Clark, D M Easty, G C Easty, A M Neville.   

Abstract

Walker carcinosarcoma cells cause in vitro osteolysis which may be inhibited by aspirin. In the rat, this tumour produces osteolytic bone deposits and hypercalcaemia, both of which can be prevented by aspirin and indomethacin, whereas soft tissue tumour deposits are unaffected by these drugs. Some human breast tumours cause in vitro osteolysis which may be inhibited by aspirin.

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Year:  1973        PMID: 4759939      PMCID: PMC2008894          DOI: 10.1038/bjc.1973.154

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  8 in total

1.  Prostaglandins: stimulation of bone resorption in tissue culture.

Authors:  D C Klein; L G Raisz
Journal:  Endocrinology       Date:  1970-06       Impact factor: 4.736

2.  Inhibition by calcitonin of bone resorption induced in vitro by vitamin A.

Authors:  J J Reynolds
Journal:  Proc R Soc Lond B Biol Sci       Date:  1968-05-14

3.  Invasion of cartilage by an experimental rat tumor.

Authors:  A R Poole
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

4.  Modifications of the acid-base status of the internal milieu of tumors.

Authors:  P M Gullino; F H Grantham; S H Smith; A C Haggerty
Journal:  J Natl Cancer Inst       Date:  1965-06       Impact factor: 13.506

5.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

6.  Effect of acetylsalicylic acid on lysosomes.

Authors:  W S Miller; J G Smith
Journal:  Proc Soc Exp Biol Med       Date:  1966-07

7.  Hypercalcaemia in patients with advanced mammary cancer.

Authors:  C S Galasko; J I Burn
Journal:  Br Med J       Date:  1971-09-04

8.  Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.

Authors:  A H Tashjian; E F Voelkel; L Levine; P Goldhaber
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307

  8 in total
  39 in total

1.  Effects of sulindac on sporadic colorectal adenomatous polyps.

Authors:  N Matsuhashi; A Nakajima; Y Fukushima; Y Yazaki; T Oka
Journal:  Gut       Date:  1997-03       Impact factor: 23.059

2.  Agents affecting osteolysis in patients with breast cancer.

Authors:  R C Coombes; A M Neville; J C Gazet; H T Ford; A G Nash; J W Baker; J T Powles
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

3.  Studies on the pathogenesis of cancer hypercalcemia.

Authors:  W P Laird Myers; R Bockman
Journal:  Trans Am Clin Climatol Assoc       Date:  1977

Review 4.  Role of prostaglandins in bone metabolism: a review.

Authors:  D Atkins; M Greaves; K J Ibbotson; T J Martin
Journal:  J R Soc Med       Date:  1979-01       Impact factor: 5.344

Review 5.  Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

Authors:  H W Seyberth
Journal:  Klin Wochenschr       Date:  1978-04-15

6.  Aspirin for reducing cancer metastases?

Authors:  U K Henschke; G J Luande; J D Choppala
Journal:  J Natl Med Assoc       Date:  1977-08       Impact factor: 1.798

7.  Calcium metabolism in breast cancer.

Authors:  R C Coombes; T J Powles; D G Joplin
Journal:  Proc R Soc Med       Date:  1977-03

8.  A comparison of indomethacin and diclofenac in the inhibition of experimental heterotopic new bone formation.

Authors:  O S Nilsson; H C Bauer; O Brosjö; H Törnkvist
Journal:  Int Orthop       Date:  1987       Impact factor: 3.075

9.  Influence of zymosan (a non-specific macrophage stimulator) and of indomethacin on liver tumours--an experimental study in rats.

Authors:  S B Holmberg; P L Naredi; G O Lindnér; I H Karlberg; P L Daneryd; L M Karlsson; A Pettersson; U Stenram; L R Hafström
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

10.  Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.

Authors:  L M Ellis; E M Copeland; K I Bland; H S Sitren
Journal:  Ann Surg       Date:  1990-07       Impact factor: 12.969

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