Literature DB >> 4749281

Inhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.

J P Infante, J E Kinsella.   

Abstract

The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.

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Year:  1973        PMID： 4749281      PMCID： PMC1177882          DOI： 10.1042/bj1340825

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.

Authors:  P G Plagemann; M F Roth
Journal:  Biochemistry       Date:  1969-12       Impact factor: 3.162

2.  The incorporation of [14C3]glycerol into lipids by dispersed bovine mammary cells.

Authors:  J E Kinsella
Journal:  Biochim Biophys Acta       Date:  1968-12-18

3.  Phenethyl alcohol: reversible inhibition of synthesis of macromolecules and disaggregation of polysomes in rat hepatoma cells.

Authors:  P G Plagemann
Journal:  Biochim Biophys Acta       Date:  1968-01-29

4.  Carrier-mediated transport of choline into synaptic nerve endings.

Authors:  I Diamond; E P Kennedy
Journal:  J Biol Chem       Date:  1969-06-25       Impact factor: 5.157

5.  Choline kinase; assay and partial purification.

Authors:  R E McCaman; S A Dewhurst; A M Goldberg
Journal:  Anal Biochem       Date:  1971-07       Impact factor: 3.365

6.  A novel stimulatory action of phosphorylcholine plus cytidine 5'-triphosphate on protein synthesis in a cell-free system.

Authors:  S Mookerjea; E Marai
Journal:  J Biol Chem       Date:  1971-05-10       Impact factor: 5.157

7.  Choline kinase and phosphorylcholine phosphatase in plants.

Authors:  K Tanaka; N E Tolbert; A F Gohlke
Journal:  Plant Physiol       Date:  1966-02       Impact factor: 8.340

8.  Effect of Cycocel derivatives and gibberellin on choline kinase and choline metabolism.

Authors:  K Tanaka; N E Tolbert
Journal:  Plant Physiol       Date:  1966-02       Impact factor: 8.340

9.  Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. 3. Choline transport and uptake by simple diffusion and lack of direct exchange with phosphatidylcholine.

Authors:  P G Plagemann
Journal:  J Lipid Res       Date:  1971-11       Impact factor: 5.922

10.  Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. II. Phosphatidylcholine synthesis during growth cycle and fluctuation of mitochondrial density.

Authors:  P G Plagemann
Journal:  J Cell Biol       Date:  1969-09       Impact factor: 10.539
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  4 in total

1.  Phospholipid synthesis in mammary tissue. Choline and ethanolamine kinases: kinetic evidence for two discrete active sites.

Authors:  J P Infante; J E Kinsella
Journal:  Lipids       Date:  1976-10       Impact factor: 1.880

2.  Control of phosphatidylcholine synthesis and the regulatory role of choline kinase in rat liver. Evidence from essential-fatty acid-deficient rats.

Authors:  J P Infante; J E Kinsella
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

3.  Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine.

Authors:  J P Infante
Journal:  Biochem J       Date:  1977-12-01       Impact factor: 3.857

4.  Effects of analogles of ethanolamine and choline on phospholipid metabolism in rat hepatocytes.

Authors:  B Akesson
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857
  4 in total

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