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Literature DB >> 603639

Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine.

Abstract

An analysis of the available data on the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine, by the logic derived from the theoretical principles of metabolic regulation, shows that the first two reactions catalysed by choline (ethanolamine) kinase and phosphocholine (phosphoethanolamine) cytidylyltransferase are rate-limiting, whereas the phosphocholine (phosphoethanolamine) transferase step is near equilibrium in rat liver.

Entities: Chemical Species

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Year: 1977 PMID： 603639 PMCID： PMC1183736 DOI： 10.1042/bj1670847

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. Phospholipid synthesis in mammary tissue. Choline and ethanolamine kinases: kinetic evidence for two discrete active sites.

Authors: J P Infante; J E Kinsella
Journal: Lipids Date: 1976-10 Impact factor: 1.880

2. The enzymatic formation of lecithin from cytidine diphosphate choline and D-1,2-diglyceride.

Authors: S B WEISS; S W SMITH; E P KENNEDY
Journal: J Biol Chem Date: 1958-03 Impact factor: 5.157

3. The function of cytidine coenzymes in the biosynthesis of phospholipides.

Authors: E P KENNEDY; S B WEISS
Journal: J Biol Chem Date: 1956-09 Impact factor: 5.157

4. Choline phosphokinase.

Authors: J WITTENBERG; A KORNBERG
Journal: J Biol Chem Date: 1953-05 Impact factor: 5.157

Review 5. Role of phospholipids in transport and enzymic reactions.

Authors: B Fourcans; M K Jain
Journal: Adv Lipid Res Date: 1974

6. The separation, purification, and characterization of ethanolamine kinase and choline kinase from rat liver.

Authors: P A Weinhold; V B Rethy
Journal: Biochemistry Date: 1974-12-03 Impact factor: 3.162

7. In vivo studies on pathways for the biosynthesis of lecithin in the rat.

Authors: P Bjørnstad; J Bremer
Journal: J Lipid Res Date: 1966-01 Impact factor: 5.922

8. Equilibrium constants under physiological conditions for the reactions of choline kinase and the hydrolysis of phosphorylcholine to choline and inorganic phosphate.

Authors: R W Guynn
Journal: J Biol Chem Date: 1976-11-25 Impact factor: 5.157

9. Thermodynamic parameters for the hydrolysis of inorganic pyrophosphate at pH 7.4 as a function of (Mg2+), (K+), and ionic strength determined from equilibrium studies of the reaction.

Authors: H Flodgaard; P Fleron
Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

10. Equilibrium relations between the cytoplasmic adenine nucleotide system and nicotinamide-adenine nucleotide system in rat liver.

Authors: R L Veech; L Raijman; H A Krebs
Journal: Biochem J Date: 1970-04 Impact factor: 3.857

18 in total

1. Tight connection between choline transport and phosphatidylcholine synthesis in MDCK cells.

Authors: P Zlatkine; C Leroy; G Moll; C Le Grimellec
Journal: Biochem J Date: 1996-05-01 Impact factor: 3.857

2. Reversibility of cholinephosphotransferase in lung microsomes.

Authors: F H Tsao
Journal: Lipids Date: 1986-08 Impact factor: 1.880

3. Control of phosphatidylcholine synthesis and the regulatory role of choline kinase in rat liver. Evidence from essential-fatty acid-deficient rats.

Authors: J P Infante; J E Kinsella
Journal: Biochem J Date: 1978-11-15 Impact factor: 3.857

4. Phosphatidylcholine biosynthesis during neuronal differentiation and its role in cell fate determination.

Authors: Hebe Marcucci; Luciana Paoletti; Suzanne Jackowski; Claudia Banchio
Journal: J Biol Chem Date: 2010-06-05 Impact factor: 5.157

5. Phospholipid synthesizing enzymes of dermatophytes: II. Characterization of choline kinase.

Authors: C Kasinathan; U Govindarajan; A Chopra; G K Khuller
Journal: Lipids Date: 1983-10 Impact factor: 1.880

6. Inhibitors of CDP-choline synthesis, action potential calcium channels, and stimulus-secretion coupling.

Authors: A de Blas; M Adler; M Shih; P K Chiang; G L Cantoni; M Nirenberg
Journal: Proc Natl Acad Sci U S A Date: 1984-07 Impact factor: 11.205

7. Ethanolamine kinase activity and compositions of diacylglycerols, phosphatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats.

Authors: J Tinoco; G Endemann; B Medwadowski; P Miljanich; M A Williams
Journal: Lipids Date: 1979-12 Impact factor: 1.880