Literature DB >> 1239345

Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis.

O Abramsky, A Aharonov, C Webb, S Fuchs.   

Abstract

Lymphocytes from patients with myasthenia gravis were stimulated when cultured in vitro with an electric eel extract enriched in acetylcholine receptor. No stimulation was observed with other antigens from nerve or muscle origin. Lymphocytes from non-myasthenic patients showed no response to any of these antigens. These findings suggest that an in vivo sensitization of lymphocytes to self acetylcholine receptor may occur in myasthenia gravis. The presence of sensitized lymphocytes, probably resulting from an autoimmune mechanism, might be an important factor in the pathogenesis of the neuromuscular block in this disease.

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Year:  1975        PMID： 1239345      PMCID： PMC1538026     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  15 in total

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Journal:  Acta Neurol Psychiatr Belg       Date:  1959-05

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Authors:  G Goldstein; W W Hofmann
Journal:  Res Publ Assoc Res Nerv Ment Dis       Date:  1971

Review 3.  Release of neurotransmitters and their interaction with receptors.

Authors:  Z W Hall
Journal:  Annu Rev Biochem       Date:  1972       Impact factor: 23.643

4.  Isolation of bovine thymin: a polypeptide hormone of the thymus.

Authors:  G Goldstein
Journal:  Nature       Date:  1974-01-04       Impact factor: 49.962

5.  Immunopharmacological disease: a break in tolerance to receptor sites.

Authors:  V A Lennon; P R Carnegie
Journal:  Lancet       Date:  1971-03-27       Impact factor: 79.321

6.  Autoimmune response to acetylcholine receptor.

Authors:  J Patrick; J Lindstrom
Journal:  Science       Date:  1973-05-25       Impact factor: 47.728

Review 7.  Myasthenia gravis as an autoimmune disease: clinical aspects.

Authors:  J A Simpson
Journal:  Ann N Y Acad Sci       Date:  1966-01-26       Impact factor: 5.691

8.  Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus.

Authors:  H Sugiyama; P Benda; J C Meunier; J P Changeux
Journal:  FEBS Lett       Date:  1973-09-01       Impact factor: 4.124

Review 9.  Studies in myasthenia gravis: biologic aspects.

Authors:  A H Rule; P Kornfeld
Journal:  Mt Sinai J Med       Date:  1971 Nov-Dec

10.  The thymus and neuromuscular function. A substance in thymus which causes myositis and myasthenic neuromuscular block in guineapigs.

Authors:  G Goldstein
Journal:  Lancet       Date:  1968-07-20       Impact factor: 79.321
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  27 in total

1.  Absence of cellular hypersensitivity to muscle and thymic antigens in myasthenia gravis.

Authors:  W M Behan; P O Behan; J A Simpson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-11       Impact factor: 10.154

2.  Mitogen and muscle extract induced in vitro proliferative responses in myasthenia gravis, dermatomyositis, and polymyositis.

Authors:  R P Lisak; B Zweiman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-06       Impact factor: 10.154

3.  Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis.

Authors:  G Landi; M Galli; G Ciboddo; G Colombo; G Scarlato
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-02       Impact factor: 10.154

4.  T and B lymphocytes in myasthenia gravis.

Authors:  Y Itoyama; S Kawanami; I Goto; Y Kuroiwa
Journal:  Clin Exp Immunol       Date:  1979-09       Impact factor: 4.330

5.  Subpopulations of T lymphocytes in myasthenia gravis patients.

Authors:  M Piantelli; L Lauriola; A Carbone; A Evoli; P Tonali; P Musiani
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330

Review 6.  Functional defect in regulatory T cells in myasthenia gravis.

Authors:  Muthusamy Thiruppathi; Julie Rowin; Qin Li Jiang; Jian Rong Sheng; Bellur S Prabhakar; Matthew N Meriggioli
Journal:  Ann N Y Acad Sci       Date:  2012-12       Impact factor: 5.691

7.  [Myasthenic syndrome during penicillamine treatment (author's transl)].

Authors:  F Schumm; M Stöhr
Journal:  Klin Wochenschr       Date:  1978-02-01

8.  Induction of the morphologic changes of both acute and chronic experimental myasthenia by monoclonal antibody directed against acetylcholine receptor.

Authors:  C M Gomez; R L Wollmann; D P Richman
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

9.  Cellular and humoral immunity to acetylcholine receptor in myasthenia gravis.

Authors:  B M Conti Tronconi; A Scotti; A Brigonzi; E Sher; G Fumagalli; D Peluchetti; F Clementi
Journal:  Ital J Neurol Sci       Date:  1982-03

10.  The relation of clinical disease to antibody titre, proliferative response and neurophysiology in murine experimental autoimmune myasthenia gravis.

Authors:  A R Pachner; F S Kantor
Journal:  Clin Exp Immunol       Date:  1983-03       Impact factor: 4.330
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