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Literature DB >> 4736109

Preparation and properties of an inhibitory extract from frog virus 3 particles.

A M Aubertin, C Hirth, C Travo, H Nonnenmacher, A Kirn.

Abstract

The structural constituents of the frog virus 3 particle were solubilized by treatment with a nonionic detergent followed by the addition of a high salt concentration. This soluble viral extract (SVE) inhibits host nucleic acid synthesis. Its activity on RNA synthesis was studied in KB cells and found to be dependent on the presence of DEAE dextran. Inactivation of the inhibitory properties of SVE were obtained by trypsin digestion, treatment with urea, or heat denaturation. Neutralization of the activity of SVE was obtained by anti-frog virus 3 serum but not by anti-BHK serum. In vitro a complex may be formed between polynucleotides and the inhibitor indicating a possible mechanism for vivo inhibition.

Entities: Chemical Species

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Year: 1973 PMID： 4736109 PMCID： PMC355165 DOI： 10.1128/JVI.11.5.694-701.1973

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

21 in total

1. The step in cellular DNA synthesis blocked by Newcastle disease or mengovirus infection.

Authors: W D Ensminger; I Tamm
Journal: Virology Date: 1970-01 Impact factor: 3.616

2. Effect of poxvirus infection on host cell deoxyribonucleic acid synthesis.

Authors: C Jungwirth; J Launer
Journal: J Virol Date: 1968-05 Impact factor: 5.103

3. Role of adenovirus structural proteins in the cessation of host-cell biosynthetic functions.

Authors: A J Levine; H S Ginsberg
Journal: J Virol Date: 1968-05 Impact factor: 5.103

4. Viruses and renal carcinoma of Rana pipiens. IV. Nucleic acid synthesis in frog virus 3-infected BHK 21/13 cells.

Authors: R Maes; A Granoff
Journal: Virology Date: 1967-11 Impact factor: 3.616

5. The step in cellular DNA synthesis blocked by reovirus infection.

Authors: W D Ensminger; I Tamm
Journal: Virology Date: 1969-12 Impact factor: 3.616

6. Mechanism by which fiber antigen inhibits multiplication of type 5 adenovirus.

Authors: A J Levine; H S Ginsberg
Journal: J Virol Date: 1967-08 Impact factor: 5.103

7. Selective inhibition of a nuclear RNA polymerase in cells infected with frog virus.

Authors: F Costanzo; M La Placa; A M Palenzoma; F Novello; F Stirpe
Journal: Nature Date: 1970-07-18 Impact factor: 49.962

8. Effect of adenovirus on host cell DNA synthesis in synchronized cells.

Authors: L D Hodge; M D Scharff
Journal: Virology Date: 1969-04 Impact factor: 3.616

9. Deoxyribonucleic acid synthesis in FV-3-infected mammalian cells.

Authors: B R McAuslan; W R Smith
Journal: J Virol Date: 1968-10 Impact factor: 5.103

10. Chromatographic separation of nucleoside phosphates on diethylaminoethylcellulose paper.

Authors: J F Morrison
Journal: Anal Biochem Date: 1968-07 Impact factor: 3.365

14 in total

1. Proteins solubilized from frog virus 3 particles: effect on transcription.

Authors: A M Aubertin; C Travo; A Kirn
Journal: J Virol Date: 1976-04 Impact factor: 5.103

2. Structure and regulation of the immediate-early frog virus 3 gene that encodes ICR489.

Authors: W Beckman; T N Tham; A M Aubertin; D B Willis
Journal: J Virol Date: 1988-04 Impact factor: 5.103

3. Crossed immunoelectrophoretic characterization of Chilo iridescent virus surface antigens.

Authors: J Guerillon; S Barray; G Devauchelle
Journal: Arch Virol Date: 1982 Impact factor: 2.574

4. Oscillation of the electric potential of frog skin under the effect of Li+: experimental approach.

Authors: J P Lassalles; A Hartmann; M Thellier
Journal: J Membr Biol Date: 1980-09-30 Impact factor: 1.843

5. Frog Virus 3 Replication: Analysis of Structural and Nonstructural Polypeptides in Infected BHK Cells by Acidic and Basic Two-Dimensional Gel Electrophoresis.

Authors: R M Elliott; R Bravo; D C Kelly
Journal: J Virol Date: 1980-01 Impact factor: 5.103