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Literature DB >> 1255875

Proteins solubilized from frog virus 3 particles: effect on transcription.

Abstract

The treatment of KB cells with viral proteins solubilized from frog virus 3 particles (SVE) induced a rapid shutoff of host RNA synthesis. The RNA polymerase activities of SVE-treated cells were drastically depressed, corresonding, at least for RNA polymerase B, to a decrease in the number of enzyme molecules. In vitro, SVE had no direct effect on RNA polymerases but was capable of binding with calf thymus DNA to form an SVE-DNA complex modifying the template capacity. The effect of SVE on a transcription system consisting of cell lysates would suggest that cytoplasmic factors are necessary for expression of the inhibitory capacity of SVE.

Entities: Disease Species

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Year: 1976 PMID： 1255875 PMCID： PMC515518 DOI： 10.1128/JVI.18.1.34-41.1976

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

21 in total

Review 1. Eukaryotic nuclear RNA polymerases.

Authors: P Chambon
Journal: Annu Rev Biochem Date: 1975 Impact factor: 23.643

2. Frog virus 3 replication: electron microscope observations on the sequence of infection in chick embryo fibroblasts.

Authors: D C Kelly
Journal: J Gen Virol Date: 1975-01 Impact factor: 3.891

3. Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins.

Authors: M Cochet-Meilhac; P Chambon
Journal: Biochim Biophys Acta Date: 1974-06-27

4. Early ultrastructural changes induced in BHK cell nuclei by frog virus 3. A possible mechanism for the impairment of cellular DNA synthesis.

Authors: G Campadelli-Fiume; M M Bragaglia; F Costanzo; L Foà; M LaPlaca
Journal: J Gen Virol Date: 1973-10 Impact factor: 3.891

10. Encephalomyocarditis virus infection of mouse plasmacytoma cells. II. Effect on host RNA synthesis and RNA polymerases.

Authors: L B Schwartz; C Lawrence; R E Thach; R G Roeder
Journal: J Virol Date: 1974-09 Impact factor: 5.103

4 in total

Review 1. Amanitins in virus research.

Authors: G Campadelli-Fiume
Journal: Arch Virol Date: 1978 Impact factor: 2.574

Proteins solubilized from frog virus 3 particles: effect on transcription.

Review 1. Eukaryotic nuclear RNA polymerases.

2. Frog virus 3 replication: electron microscope observations on the sequence of infection in chick embryo fibroblasts.

3. Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins.

4. Early ultrastructural changes induced in BHK cell nuclei by frog virus 3. A possible mechanism for the impairment of cellular DNA synthesis.

5. Two functional states of the RNA polymerases in the rat hepatic nuclear and nucleolar fractions.

6. The Chanock Centre for Virology, Hebrew University. Hadassah Medical School, Jerusalem, Israel.

7. Prolonged transcription in a cell-free system involving nuclei and cytoplasm.

8. Modifications of cellular RNA-polymerase II after infection with frog virus 3.

9. The rapid turnover of RNA polymerase of rat liver nucleolus, and of its messenger RNA.

10. Encephalomyocarditis virus infection of mouse plasmacytoma cells. II. Effect on host RNA synthesis and RNA polymerases.

Review 1. Amanitins in virus research.

2. Nucleotide sequence of an immediate-early frog virus 3 gene.

3. Inhibition of macromolecular synthesis in cells infected with an invertebrate virus (iridovirus type 6 or CIV).

4. Frog virus 3 requires RNA polymerase II for its replication.