Literature DB >> 4724596

Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.

B M Buckley, D H Williamson.   

Abstract

The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.

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Year:  1973        PMID： 4724596      PMCID： PMC1177633          DOI： 10.1042/bj1320653

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase.

Authors:  J R STERN; M J COON; A DEL CAMPILLO; M C SCHNEIDER
Journal:  J Biol Chem       Date:  1956-07       Impact factor: 5.157

2.  Changes in D(--)-beta-hydroxybutyric dehydrogenase activity during brain maturation in the rat.

Authors:  C B Klee; L Sokoloff
Journal:  J Biol Chem       Date:  1967-09-10       Impact factor: 5.157

3.  Enzymes of ketone-body utilisation in human brain.

Authors:  M A Page; D H Williamson
Journal:  Lancet       Date:  1971-07-10       Impact factor: 79.321

4.  CoA transferase in the brain and other mammalian tissues.

Authors:  J T Tildon; D A Sevdalian
Journal:  Arch Biochem Biophys       Date:  1972-02       Impact factor: 4.013

5.  A role of acetoacetyl-CoA synthetase in acetoacetate utilization by rat liver cell fractions.

Authors:  J R Stern
Journal:  Biochem Biophys Res Commun       Date:  1971-08-20       Impact factor: 3.575

6.  Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.

Authors:  D H Williamson; M W Bates; M A Page; H A Krebs
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

7.  Acetyl transport mechanisms in the nervous system. The oxoglutarate shunt and fatty acid synthesis in the developing rat brain.

Authors:  A F D'Adamo; A P D'Adamo
Journal:  J Neurochem       Date:  1968-04       Impact factor: 5.372

8.  Coenzyme A transferase activity in rat brain.

Authors:  J T Tildon; A L Cone; M Cornblath
Journal:  Biochem Biophys Res Commun       Date:  1971-04-02       Impact factor: 3.575

9.  Brain metabolism during fasting.

Authors:  O E Owen; A P Morgan; H G Kemp; J M Sullivan; M G Herrera; G F Cahill
Journal:  J Clin Invest       Date:  1967-10       Impact factor: 14.808

10.  Ketone-body utilization by adult and suckling rat brain in vivo.

Authors:  R A Hawkins; D H Williamson; H A Krebs
Journal:  Biochem J       Date:  1971-03       Impact factor: 3.857
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  23 in total

1.  Inhibition of sterol but not fatty acid synthesis by valproate in developing rat brain in vivo.

Authors:  J P Bolaños; J M Medina; D H Williamson
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

2.  Ketone bodies serve as important precursors of brain lipids in the developing rat.

Authors:  Y Y Yeh; V L Streuli; P Zee
Journal:  Lipids       Date:  1977-11       Impact factor: 1.880

3.  Lipogenesis from ketone bodies in rat brain. Evidence for conversion of acetoacetate into acetyl-coenzyme A in the cytosol.

Authors:  M S Patel; O E Owen
Journal:  Biochem J       Date:  1976-06-15       Impact factor: 3.857

4.  Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland.

Authors:  A M Robinson; D H Williamson
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

5.  Short-chain fatty acid synthesis in brain. Subcellular localization and changes during development.

Authors:  G L Reijnierse; H Veldstra; C J Van der Ber
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

6.  Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development.

Authors:  D H Williamson; V Ilic
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

7.  Ketone-body metabolism in glioma and neuroblastoma cells.

Authors:  M S Patel; J J Russell; H Gershman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

8.  Pathways of acetyl CoA production for lipogenesis from acetoacetate, beta-hydroxybutyrate, pyruvate and glucose in neonatal rat lung.

Authors:  P M Sheehan; Y Y Yeh
Journal:  Lipids       Date:  1984-02       Impact factor: 1.880

9.  Lipogenesis in the brain of suckling rats. Studies on the mechansim of mitochondrial-cytosolic carbon transfer.

Authors:  T B Patel; J B Clark
Journal:  Biochem J       Date:  1980-04-15       Impact factor: 3.857

10.  A double-isotope method for the measurement of ketone-body turnover in the rat. Effect of L-alanine.

Authors:  W D Reed; P J Baab; R L Hawkins; P T Ozand
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857
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