Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Brain metabolism during fasting.

Literature DB >> 6061736

Brain metabolism during fasting.

O E Owen, A P Morgan, H G Kemp, J M Sullivan, M G Herrera, G F Cahill.

Abstract

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1967 PMID： 6061736 PMCID： PMC292907 DOI： 10.1172/JCI105650

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

18 in total

1. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

Authors: D H WILLIAMSON; J MELLANBY; H A KREBS
Journal: Biochem J Date: 1962-01 Impact factor: 3.857

2. Carbon dioxide fixation in the brain.

Authors: S BERL; G TAKAGAKI; D D CLARKE; H WAELSCH
Journal: J Biol Chem Date: 1962-08 Impact factor: 5.157

3. A study in man of cerebral blood flow and cerebral glucose, lactate and pyruvate metabolism before and after eating.

Authors: G G ROWE; G M MAXWELL; C A CASTILLO; D J FREEMAN; C W CRUMPTON
Journal: J Clin Invest Date: 1959-12 Impact factor: 14.808

4. The oxidation of ketone bodies by mitochondria from liver and peripheral tissues.

Authors: W P MCCANN
Journal: J Biol Chem Date: 1957-05 Impact factor: 5.157

5. Cerebral metabolism of isotopic glucose in normal human subjects.

Authors: W SACKS
Journal: J Appl Physiol Date: 1957-01 Impact factor: 3.531

6. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.

Authors: S MOORE; W H STEIN
Journal: J Biol Chem Date: 1954-12 Impact factor: 5.157

7. Substrate and enzyme distribution in cells and cell fractions of the nervous system.

Authors: L G ABOOD; R W GERARD; J BANKS; R D TSCHIRGI
Journal: Am J Physiol Date: 1952-03

8. [Glucose consumption of the human brain under the influence of intravenous infusions of glucose, glucagon and glucose-insulin].

Authors: U Gottstein; K Held; H Sebening; G Walpurger
Journal: Klin Wochenschr Date: 1965-09-15

9. Pyruvate carboxylase activity of mammalian brain cortex.

Authors: R A Felicioli; F Gabrielli; C A Rossi
Journal: Life Sci Date: 1967-01-15 Impact factor: 5.037

10. Hormone-fuel interrelationships during fasting.

Authors: G F Cahill; M G Herrera; A P Morgan; J S Soeldner; J Steinke; P L Levy; G A Reichard; D M Kipnis
Journal: J Clin Invest Date: 1966-11 Impact factor: 14.808

327 in total

1. Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates.

Authors: P H Sugden; E A Newsholme
Journal: Biochem J Date: 1975-07 Impact factor: 3.857

2. Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation.

Authors: Chris J Reisenauer; Dhaval P Bhatt; Dane J Mitteness; Evan R Slanczka; Heidi M Gienger; John A Watt; Thad A Rosenberger
Journal: J Neurochem Date: 2011-02-24 Impact factor: 5.372

Review 3. Hypoglycaemia of the newborn: a review.

Authors: A F Williams
Journal: Bull World Health Organ Date: 1997 Impact factor: 9.408

4. Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.

Authors: Takashi Matsui; Hideki Omuro; Yu-Fan Liu; Mariko Soya; Takeru Shima; Bruce S McEwen; Hideaki Soya
Journal: Proc Natl Acad Sci U S A Date: 2017-05-17 Impact factor: 11.205

5. Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain.

Authors: Jennifer N Jernberg; Caitlyn E Bowman; Michael J Wolfgang; Susanna Scafidi
Journal: J Neurochem Date: 2017-07-12 Impact factor: 5.372

6. Fatty acid metabolism in the perfused rat liver.

Authors: H A Krebs; R Hems
Journal: Biochem J Date: 1970-09 Impact factor: 3.857

7. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat.

Authors: K Sofia Appelberg; David A Hovda; Mayumi L Prins
Journal: J Neurotrauma Date: 2009-04 Impact factor: 5.269

8. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

Authors: R A DeFronzo; R Gunnarsson; O Björkman; M Olsson; J Wahren
Journal: J Clin Invest Date: 1985-07 Impact factor: 14.808

9. Effect of insulin on the distribution and disposition of glucose in man.

Authors: E Ferrannini; J D Smith; C Cobelli; G Toffolo; A Pilo; R A DeFronzo
Journal: J Clin Invest Date: 1985-07 Impact factor: 14.808

10. D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.

Authors: Kim Tieu; Celine Perier; Casper Caspersen; Peter Teismann; Du-Chu Wu; Shi-Du Yan; Ali Naini; Miquel Vila; Vernice Jackson-Lewis; Ravichandran Ramasamy; Serge Przedborski
Journal: J Clin Invest Date: 2003-09 Impact factor: 14.808