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Literature DB >> 4724595

Concentrations of asparagine in tissues of prepubertal rats after enzymic or dietary depletion of asparagine.

Abstract

Growth of weanling rats was significantly depressed after 8 days of asparagine depletion produced by dietary means or by asparaginase treatment. Moreover, the concentration of free asparagine was significantly lowered in forebrain, skeletal muscle, liver, kidney, spleen and small intestines 3 h after an asparaginase injection, but remained lowered only in forebrain and skeletal muscle after 8 days of enzymic or dietary depletion of asparagine.

Entities: Chemical Disease Species

Mesh：

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Year: 1973 PMID： 4724595 PMCID： PMC1177631 DOI： 10.1042/bj1320645

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. THE ROLE OF DISPENSABLE AMINO ACIDS IN THE NUTRITION OF THE RAT.

Authors: L H Breuer; W G Pond; R G Warner; J K Loosli
Journal: J Nutr Date: 1964-04 Impact factor: 4.798

2. An enzymatic method for the measurement of asparagine and a new assay of asparaginase activity.

Authors: Y Kojima; W E Wacker
Journal: J Lab Clin Med Date: 1969-09

3. Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.

Authors: M K Patterson; G R Orr
Journal: Cancer Res Date: 1969-06 Impact factor: 12.701

4. Hepatic RNA metabolism in male and female obese rats fed cholesterol.

Authors: L C Fillios; O Yokono
Journal: J Nutr Date: 1968-07 Impact factor: 4.798

5. The importance of dispensable amino acids for maximal growth in the rat.

Authors: Q R Rogers; D M Chen; A E Harper
Journal: Proc Soc Exp Biol Med Date: 1970-06

6. Effect of L-asparaginase on DNA synthesis in regenerating liver and in other dividing tissues.

Authors: F F Becker; R Baserga; J D Broome
Journal: Cancer Res Date: 1970-01 Impact factor: 12.701

7. The dependence of DNA and RNA synthesis on protein synthesis in asparaginase-treated lymphoma cells.

Authors: K A Ellem; A M Fabrizio; L Jackson
Journal: Cancer Res Date: 1970-02 Impact factor: 12.701

8. Relationship between nucleic acids, histone and non-histone protein synthesis in human lymphocytes stimulated with phytohemagglutinin.

Authors: A B Mukherjee
Journal: Can J Genet Cytol Date: 1970-03

Concentrations of asparagine in tissues of prepubertal rats after enzymic or dietary depletion of asparagine.

1. THE ROLE OF DISPENSABLE AMINO ACIDS IN THE NUTRITION OF THE RAT.

2. An enzymatic method for the measurement of asparagine and a new assay of asparaginase activity.

3. Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.

4. Hepatic RNA metabolism in male and female obese rats fed cholesterol.

5. The importance of dispensable amino acids for maximal growth in the rat.

6. Effect of L-asparaginase on DNA synthesis in regenerating liver and in other dividing tissues.

7. The dependence of DNA and RNA synthesis on protein synthesis in asparaginase-treated lymphoma cells.

8. Relationship between nucleic acids, histone and non-histone protein synthesis in human lymphocytes stimulated with phytohemagglutinin.

9. Evaluation of L-asparagine metabolism in animals and man.

10. L-asparaginase: inhibition of early mitosis in regenerating rat liver.

1. The potentiation of growth hormone by asparagine and tryptophan.

Review 2. Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis).